The Better Than Ever (BTE) training program is a fitness training and fundraising program designed to help make walking, running or biking a regular part life. The program also raises funds to support investigator-initiated clinical trials.
For 2014, the BTE research grants will supplement the NCI Cancer Center Support Grant pilot program. The grant review committee, and all of us at the University of Arizona Cancer Center are very grateful for the support of our BTE participants. This year's awards bring the 13-year grant distribution total to more than $1.8 million.
Pavani Chalasani, MD, MPH – Correlation of PI3K/Akt/mTOR pathway activation with response to neoadjuvant endocrine therapy in POWER-PIINC trial – Study of resistance to endocrine therapy in breast cancer is both an area of clinical need and one of major research interest.
Development and validation of biomarkers which can predict activation and response to treatment with inhibitors of PI3K/Akt/mTOR pathway are crucial to identify patients who might benefit from such therapy.
Dr. Chalasani will be testing the clinical utility of phosphatase and tensin homolog (PTEN) and phosphorylated-S6 kinase1 quantification by immunohistochemical analysis, as biomarkers for activation of PI3K/Akt/mTOR pathway, for predicting response to neoadjuvent endocrine therapy in breast cancer patients.