Associate Professor, Medicine
Director, Division of Genetic Consultation and Counseling
Assistant Professor, Nutritional Sciences
Assistant Professor, Cancer Biology - GIDP
Assistant Professor, Genetics - GIDP
Dr. Laukaitis' professional goal is to understand the genetic and environmental risk factors that predispose individuals to cancer in order to treat neoplasia before cancer develops. Her training and board certification in Medical Genetics have provided her with expertise, and to experience caring for people at high-risk for breast and other cancers due to mutations in BRCA1, BRCA2, APC and mismatch repair genes. In Dr. Laukaitis' laboratory, they seek explanations for high-risk families without identified mutations.
Dr. Laukaitis has experience working with WBF and UDCA sample genotyping and experience interpreting genetic data that influences cancer risk.
My professional goal is to provide individual risk assessment and counseling to develop a plan for treating neoplasia before metastatic cancer develops in people at high-risk of cancer because of genetic factors. My training and board certification in Medical Genetics have provided me with expertise and experience caring for people at high-risk for breast cancer due to mutations in BRCA1, BRCA2, APC and mismatch repair genes genes. I will couple this with my laboratory background to translate advances understanding additional genes influencing cancer risk into new clinical tests for my patients. I will seek to apply these advances to all of my patients, regardless of racial, ethnic, or socio-economic background.
A second research direction addresses appropriate targeting of chemoprevention strategies. I am participating in a project to test the safety of using DFMO and sulindac as a chemopreventive strategy in children with FAP, which we hope to follow with a study of efficacy.
Visit the Laukaitis Laboratory site to learn more
Publications most relevent to current research
- Burton BK, et al. A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency. N Engl J Med. 2015 Sep 10;373(11):1010-20. doi: 10.1056/NEJMoa1501365. PubMed PMID: 26352813.
- Laukaitis, C.M. (2012) Genetics for the General Internist. American Journal of Medicine 125(1):7-13. PMID: 22079017.
- Laukaitis, C.M., Erdman, S.H. and Gerner, E.W. (2012) Chemoprevention in patients with genetic risk of colorectal cancers. Colorectal Cancer 1(3):241-256.
- Laukaitis, C.M. and Gerner, E.W. (2011) DFMO: Targeted Risk Reduction Therapy. Best Practice and Research: Clinical Gastroenterology. 25(4-5):495-506. PMID: 22122766.
- Zhou, X., Wei, Y., Xie, F., Laukaitis, C.M., Karn, R.C., Kluetzman, K., Gu, J., Zhang, Q-Y., Roberts, D.W., and Ding, X. (2011) A Novel Defensive Mechanism against Acetaminophen Toxicity in the Mouse Lateral Nasal Gland: Role of CYP2A5-Mediated Regulation of Testosterone Homeostasis and Salivary Androgen-Binding Protein Expression. Molecular Toxicology. 79(4):710-23. PMID: 21252290
- Karn, R.C. and Laukaitis, C.M. (2011) Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes. PLoS One. 6(6):e20979. PMID: 21695125
Additional recent publications of importance to the field
- Laukaitis, C. M., Critser, E. S. and Karn, R. C. (1997) Salivary androgen-binding protein (ABP) mediates sexual isolation in Mus Musculus. Evolution. 51(16): 2000-2005.
- Knight, B., Laukaitis, C. M., Akhtar, N., Hotchin, N. A., Edlund, M. and Horwitz, A. R. (2000) Visualizing cell migration in situ. Current Biology. 10: 576-585. PMID: 10837222
- Laukaitis, C. M., Donais, K., Webb, D. J., and Horwitz, A. F. (2001) Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells. Journal of Cell Biology. 153(7):1427-1440. PMID: 11425873
- Laukaitis, C.M., Dlouhy, S.R., and Karn, R.C. (2003) The mouse salivary androgen-binding protein (ABP) gene cluster on chromosome 7: Characterization and evolutionary relationships. Mammalian Genome. 14:679-691. PMID: 14694904
- Laukaitis, C.M., Dlouhy, S.R., Emes, R.D., Ponting, C.P., and Karn, R.C. (2005) Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus. BMC Evolutionary Biology. 5:40. PMID: 16018816
- Laukaitis, C.M., Heger, A., Blakley, T.D., Munclinger, P., Ponting, C.P., and Karn, R.C. (2008) Rapid bursts of Abp gene duplication occurred independently in diverse mammals. BMC Evolutionary Biology. 8:46. PMID: 18269759
- Karn, R.C. and Laukaitis, C.M. (2009) The mechanism of expansion and the volatility it created in three pheromone gene clusters in the mouse (Mus musculus) genome. Genome Biology and Evolution. 2009:494-503. PMID: 20333217
- Karn, R.C., Young, J.M. and Laukaitis, C.M. (2010) A candidate subspecies discrimination system involving a vomeronasal receptor gene with different alleles fixed in M. m. domesticus and M. m. musculus. PLoS One. 5(9): e12638. PMID: 20844586
- Vošlajerová Bímová, B., Macholán, M., Baird, S.E.B., Munclinger, P., Laukaitis, C.M., Karn, R.C., Luzynski, K., Tucker, P., Piálek, J. (2011) Reinforcement selection acting on the European house mouse hybrid zone. Molecular Ecology. 20(11):2403-24. PMID: 21521395
- Karn, R.C., Mauss, C. and Laukaitis, C.M. (2012) Congenic strain analysis reveals genes that are rapidly evolving components of a prezygotic isolation mediating incipient reinforcement. PLoS One. 7(4):e35898.
2014-present Laboratory Co-Director, Clinical Laboratory of the University of Arizona Genomics Core, Tucson, AZ
2014-present Investigator, University of Arizona Cancer Center, University of Arizona, Tucson, AZ
2012-2013 Associate Program Director, Internal Medicine Residency Program, Univ. Arizona, Tucson, AZ
2010-present Assistant Professor, Tenure Eligible, Department of Medicine, University of Arizona, Tucson, AZ
2009-present Member, Genetics Interdisciplinary Training Program, Univ. of Arizona, Tucson, AZ
2009-present Member, Cancer Biology Interdisciplinary Training Program, Univ. of Arizona, Tucson, AZ
2008-2013 Associate Investigator, Arizona Cancer Center, University of Arizona, Tucson, AZ
2008-2010 Assistant Professor of Clinical Medicine, Dept. of Medicine, University of Arizona, Tucson, AZ
2008-2009 Postdoctoral Research, Fred Hutchinson Cancer Research Center, Seattle, WA
2006-2008 Fellow, Division of Medical Genetics, University of Washington, Seattle, WA
2006 Locum tenens physician, Hopi Health Care Center, Polacca, AZ
2004-2006 Resident, Internal Medicine, St. Vincent Hospital, Indianapolis, IN
2003-2004 Intern, Internal Medicine Residency Program, St. Vincent Hospital, Indianapolis, IN
1995-2001 Graduate & Teaching Assistant, Dept. of Cell & Structural Biology, Univ. of Illinois, Urbana, IL
2011 40 under 40, Arizona Star, recognizes young leaders in Tucson based on professional accomplishments, leadership qualities and community impact.
2011 Yellen Distinguished Young Investigator Award, Arizona Cancer Center; Unrestricted use gift
2010-2011 Young Alumni Board, Butler University, Indianapolis, IN
2005 Summer Institute in Statistical Genetics, North Carolina State University, Raleigh, NC (Basic statistics, Genetic data analysis, Molecular phylogenetics)
1991-1995 National Science Scholar, National Science Foundation
2011-Present Member, International Society for Gastrointestinal Hereditary Tumors (InSiGHT)
2011-Present Member, Collaborative Group of the Americas on Inherited Colorectal Cancer
2011-Present Fellow, American College of Physicians
2009 Diplomate, American Board of Medical Genetics
2008-Present Member, Arizona State Genetic Services Advisory Committee
2007-Present Member, American Society for Human Genetics
2007-2011 Member, American College of Physicians
2006-Present Member, Genetics Society of America
2006 Diplomate, American Board of Internal Medicine
2003-Present Member, European Society for Evolutionary Biology
2001-Present Member, Society for the Study of Evolution