Associate Professor, Child Health - (Research Scholar Track)
As part of a precision medicine approach to identify novel therapeutic targets and improve treatment options for pediatric cancers, Dr. Aleem’s translational research focuses on (1) understanding the association between cancer genotype and phenotype, i.e. how the genomic/transcriptomic alterations in cancer cells lead to cancer-specific biological effects, such as uncontrolled cell proliferation, drug resistance and escape from apoptosis, (2) Identification of drugs targeting cancer stem cells and studying the mechanisms of action of drugs currently in clinical trials, as well as (3) studying the effect of the tumor microenvironment on the response of cancer cells to therapy. Dr. Aleem applies a variety of innovative technologies in her research including next-generation sequencing, functional proteomics, kinome profiling, in vitro 3D cell culture models and in vivo mice models. Current projects in the lab include: (1) Integrating Functional Proteomics To Identify Novel Therapeutic Targets in AML, (2) Development Of An In Vitro Microenvironment Assay For Accurate Drug Response Testing, (3) Targeting Novel Mechanisms of Cell Death in Pediatric Cancer.
Dr. Aleem received her Ph. D. in molecular biology from Heidelberg University and the German Cancer Research Center (DKFZ), Germany working on the insulin and insulin-like growth factor-1 receptor (IGF-1R) signaling in liver cancer. She received a postdoctoral fellowship from the NIH at NCI-Frederick, to study the regulation of the mammalian cell cycle using knockout mouse models. Dr. Aleem was a Professor at Alexandria University, Egypt and a Senior Scientist and Associate Professor at Karolinska Institutet, Stockholm, Sweden, where she continued her work on the IGF-1R functions in stem cells and its therapeutic targeting in cancer.