Eugene A Mash, PhD

Professor, Chemistry and Biochemistry-Sci
Email Address: 
Phone Number: 
(520) 621-6321

UACC Information

UACC Organizational Unit(s): 
Professional Bio: 

Dr. Mash is a Professor of Chemistry and Biochemistry.  He received his Ph.D. in Chemistry from the University of Utah in 1980 for work on the mechanism of terpene biosynthesis with Prof. C. Dale Poulter.  He was an NIH postdoctoral fellow at Harvard University from 1981 to 1983 and worked with Prof. E. J. Corey on a total synthesis of Saframycin B.  As an independent scholar in the Chemistry and Biochemistry Department at the University of Arizona for the past 32+ years, Dr. Mash has become a world-renowned expert in synthetic organic chemistry.  He is also a member of the Arizona Cancer Center. 

Dr. Mash has published more than 140 peer-reviewed articles in scientific journals, many in collaboration with cancer biologists.  His current interests include imaging of and drug delivery to disease-related sites in the gastrointestinal tract.

Research Information

Research Program: 
Therapeutic Development
Member Status: 
Associate Research Member
Selected Publications: 
  1. Dehigaspitiya, D. C.; Anglin, B. L.; Smith, K. R.; Weber, C. A.; Lynch, R. M.; Mash, E. A. Org. Biomol. Chem. 2015, 13, 0000-0000. "Linear Scaffolds for Multivalent Targeting of Melanocortin Receptors."
  2. Elshan, N. G. R. D.; Jayasundera, T.; Weber, C. A.; Lynch, R. M.; Mash, E. A. Bioorg. Med. Chem. 2015, 23, 1841-1848. "Development of a Time-resolved Fluorescence Probe for Evaluation of Competitive Binding to the Cholecystokinin 2 Receptor."
  3. Dehigaspitiya, D. C.; Navath, S.; Weber, C. A.; Lynch, R. M.; Mash, E. A. Tetrahedron. Lett. 2015, 56, 3060-3065. "Synthesis and Bioactivity of MSH4 Oligomers Prepared by an A2 + B2 Strategy."
  4. Elshan, N. G. R. D.; Jayasundera, T.; Anglin, B. L.; Weber, C. A.; Lynch, R. M.; Mash, E. A. Org. Biomol. Chem. 2015, 13, 1778-1791. "Trigonal Scaffolds for Multivalent Targeting of Melanocortin Receptors."
  5. Elshan, N. G. R. D.; Patek, R.; Vagner, J.; Mash, E. A. Anal. Biochem. 2014, 464, 24-29. "Spectrophotometric Determination and Removal of Unchelated Europium Ions from Solutions Containing Eu-Diethylenetriaminepentaacetic Acid Chelate-Peptide Conjugates."
  6. Jagadish, B.; Ozumerzifon, T. J.; Roberts, S. A.; Hall, G. B.; Mash, E. A.; Raghunand, N. Synthetic Communic. 2014, 44, 441-449. "Improved Synthesis of 10-(2-Alkylamino-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid Derivatives Bearing Acid-sensitive Linkers."
  7. Jagadish, B.; Field, J. A.; Chorover, J.; Sierra-Alvarez, R.; Abrell, L.; Mash, E. A. J. Label. Compd. Radiopharm. 2014, 57, 434-436. "Synthesis of 13C and 15N Labeled 2,4-Dinitroanisole."
  8. Mash, E. A. CrystEngComm 2014, 16, 8620-8637. "Crystal Engineering with 1,4-Piperazine-2,5-diones."
  9. Alleti, R.; Vagner, J.; Dehigaspitiya, D. C.; Moberg, V. E.; Elshan, N. G. R. D.; Tafreshi, N. K.; Brabez, N.; Weber, C. S.; Lynch, R. M.; Hruby, V. J.; Gillies, R. J.; Morse, D. L.; Mash, E. A. Bioorg. Med. Chem. 2013, 21, 5029-5038. "Synthesis and Characterization of Time-resolved Fluorescence Probes for Evaluation of Competitive Binding to Melanocortin Receptors."
  10. Martinez, G. V.; Navath, S.; Sewda, K.; Rao, V.; Foroutan, P.; Alleti, R.; Moberg, V. E.; Ahad, A. M.; Coppola, D.; Lloyd, M. C.; Gillies, R. J.; Morse, D. L.; Mash, E. A. Bioorg. Med. Chem. Lett. 2013, 23, 2061-2064. "Demonstration of a Sucrose-derived Contrast Agent for Magnetic Resonance Imaging of the GI Tract."
  11. Navath, S.; Rao, V.; Woodford, R. T.; Midura-Kiela, M. T.; Ahad, A. M.; Alleti, R.; Kiela, P. R.; Mash, E. A. ACS Med. Chem. Lett. 2012, 3, 710-714. "Design, Synthesis, and Testing of a Molecular Truck for Colonic Delivery of 5-Aminosalicylic Acid."
  12. Mash, E. A. (2012) "Synthetically Derived Chiral Auxiliaries: Uses of Derivatives of Non-Carbohydrate Aldehydes and Ketones in Asymmetric Synthesis." In: Carreira E.M. and Yamamoto H. (eds.) Comprehensive Chirality, Volume 3, pp. 377-407; Amsterdam: Elsevier.
  13. Wells, K.E.; Weatherhead, R. A.; Murigi, F. N.; Nichol, G. S.; Carducci, M. D.; Selby, H. D.; Mash, E. A. Cryst. Growth Des. 2012, 12, 5056-5068. "Organic Crystal Engineering with 1,4-Piperazine-2,5-diones. 8. Synthesis, Crystal Packing, and Thermochemistry of Piperazinediones Derived from 2-Amino-4,7-dialkoxyindan-2-carboxylic Acids."
  14. Jagadish, B.; Guntle, G. P.; Zhao, D.; Gokhale, V.; Ozumerzifon, T. J.; Ahad, A. M.; Mash, E. A.; Raghunand, N. J. Med. Chem. 2012, 55, 10378-10386. "Redox-active Magnetic Imaging Contrast Agents: Studies with Thiol-bearing 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetracetic Acid Derivatives."
  15. Jagadish, B.; Brickert-Albrecht, G. L.; Nichol, G. S.; Mash, E. A.; Raghunand, N. Tetrahedron Lett. 2011, 52, 2058-2061. "On the Synthesis of 1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane."
  16. Rao, V.; Alleti, R.; Xu, L.; Tafreshi, N. K.; Morse, D. L.; Gillies, R. J.; Mash, E. A. Bioorg. Med. Chem. 2011, 19, 6474-6482. "A Sucrose-Derived Scaffold for Multimerization of Bioactive Peptides."
  17. Alleti, R.; Rao, V.; Xu, L.; Gillies, R. J.; Mash, E. A. J. Org. Chem. 2010, 75, 5895-5903. "A Solanesol-Derived Scaffold for Multimerization of Bioactive Peptides."
  18. Raghunand, N.; Guntle, G. P.; Gokhale, V.; Nichol, G. S.; Mash, E. A.; Jagadish, B. J. Med. Chem. 2010, 53, 6747-6757. "Design, Synthesis, and Evaluation of 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic Acid-Derived, Redox-Sensitive Contrast Agents for Magnetic Resonance Imaging."
  19. Murigi, F. N.; Nichol, G. S.; Mash, E. A. J. Org. Chem. 2010, 75, 1293-1296. "Synthesis of the Conformationally Constrained Tyrosine Analogs, (R)- and (S)-5-Hydroxy-2-aminoindan-2-carboxylic Acids."
  20. Weatherhead, R. A.; Carducci, M. D.; Mash, E. A. J. Org. Chem. 2009, 74, 8773-8778. "Synthesis of Conformationally Constrained Diaminodicarboxylic Acid Derivatives."
  21. Jones, I. W.; Lynn, M. A.; Mash, E. A. Tetrahedron 2009, 65, 10317-10322. "Conformational Analysis of Bridgehead-substituted Bicyclo[m.m.m]alkanes and Bicyclo[8.8.n]alkanes."
  22. Ntirampebura, D.; Jagadish, B.; Nichol, G. S.; Carducci, M. D.; Dawson, A.; Rajapakshe, A.; Oliver, A. G.; Clegg, W.; Harrington, R. W.; Layne Jr., L.; Margolis, J. I.; Mash, E. A. Crystal Growth & Design 2008, 8, 3257-3270. "Organic Crystal Engineering with Piperazine-2,5-diones. 7. Crystal Packing of Piperazinediones Derived from 2-Amino-7-nitro-4-methoxyindan-2-carboxylic Acid."

Academic Information

Post Doctoral: 
Harvard University
Doctorate: 
Chemistry, University of Utah, Salt Lake City, UT
Undergraduate School: 
BS Biology/BA Chemistry University of California, Irvine, CA