Dr. Fares is a Professor of Molecular and Cellular Biology and a member of the University of Arizona Cancer Center. The goal of his studies is to decipher a novel cell biological pathway linking regulators of endosomal and lysosomal transport; this will advance the field of membrane transport, identify the basis for tissue-specific death in some diseases, and identify potential therapies for the lysosomal storage disorder Mucolipidosis type IV.
Dr. Fares established the C. elegans model of this disease ten years ago and his group has made significant contributions in using it to elucidate functions of the Mucolipidosis type IV protein (TRPML1/mucolipin-1 in mammals and CUP-5 in C. elegans) and to understand the basis of the Mucolipidosis type IV lysosomal dysfunction and tissue degeneration.
Furthermore, he has significant experience in genetic and cell biological analyses of membrane trafficking in C. elegans. In summary, he has a demonstrated record of productive research projects in Mucolipidosis type IV and membrane trafficking.
Lysosomal Storage Disorders
- Miller, A., Schafer, J, Upchurch, C., Spooner, E., Huynh, J., Hernandez, S., McLaughlin, B., Oden, L., and Fares, H. (2015). Mucolipidosis type IV protein TRPML1-dependent lysosome formation. Traffic 16, 284-297. PMID: 25491304
- Spooner, E., McLaughlin, B., Lepow, T., Durns, T. A., Randall, J., Upchurch, C., Miller, K., Campbell, E. M., and Fares, H. (2013). Systematic Screens for Proteins that Interact with the Mucolipidosis type IV protein TRPML1. PLOS ONE 8, e56780. PMCID: PMC3572064
- Campbell, E. M. and Fares, H. (2010). Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis. BMC Cell Biology 11:40. PMCID: PMC2891664
- Thompson, E. G., Schaheen, L., Dang, H., and Fares, H. (2007). Lysosomal Trafficking Functions of mucolipin-1 in Murine Macrophages. BMC Cell Biology 8:54. PMID: 18154673
- Schaheen, L., Patton, G., and Fares, H. (2006). Suppression of the cup-5 Mucolipidosis Type IV-related lysosomal dysfunction by the inactivation of an ABC Transporter in C. elegans. Development 133, 3939-3948. PMID: 16943270
- Schaheen, L., Dang, H., and Fares, H. (2006). Basis of lethality in C. elegans lacking CUP-5, the Mucolipidosis Type IV orthologue. Developmental Biology 293, 382-391. PMID: 16530747
- Treusch, S., Knuth, S., Slaugenhaupt, S. A., Goldin, E., Grant, B. D., and Fares, H. (2004). Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis. Proceedings of the National Academy of Science, USA 101, 4483-4488. PMID: 15070744