Hanna (Johnny) Fares, PhD

Professor, Department of Molecular and Cellular Biology
Email Address: 
FAX: 
(520) 621-3709

UACC Information

UACC Organizational Unit: 
Professional Bio: 

Dr. Fares is a Professor of Molecular and Cellular Biology and a member of the University of Arizona Cancer Center.  The goal of his studies is to decipher a novel cell biological pathway linking regulators of endosomal and lysosomal transport; this will advance the field of membrane transport, identify the basis for tissue-specific death in some diseases, and identify potential therapies for the lysosomal storage disorder Mucolipidosis type IV. 

Dr. Fares established the C. elegans model of this disease ten years ago and his group has made significant contributions in using it to elucidate functions of the Mucolipidosis type IV protein (TRPML1/mucolipin-1 in mammals and CUP-5 in C. elegans) and to understand the basis of the Mucolipidosis type IV lysosomal dysfunction and tissue degeneration. 

Furthermore, he has significant experience in genetic and cell biological analyses of membrane trafficking in C. elegans.  In summary, he has a demonstrated record of productive research projects in Mucolipidosis type IV and membrane trafficking.

Research Information

Research Program: 
Cancer Biology
Member Status: 
Research Member
Year of Membership Acceptance: 
2001
Summary of Research Activity: 

Lysosomal Storage Disorders

Selected Publications: 

Dr. Fares' NCBI bibliography

  1. Miller, A., Schafer, J, Upchurch, C., Spooner, E., Huynh, J., Hernandez, S., McLaughlin, B., Oden, L., and Fares, H.  (2015). Mucolipidosis type IV protein TRPML1-dependent lysosome formation.  Traffic 16, 284-297.  PMID: 25491304
  2. Spooner, E., McLaughlin, B., Lepow, T., Durns, T. A., Randall, J., Upchurch, C., Miller, K., Campbell, E. M., and Fares, H.  (2013). Systematic Screens for Proteins that Interact with the Mucolipidosis type IV protein TRPML1.  PLOS ONE 8, e56780.  PMCID: PMC3572064
  3. Campbell, E. M. and Fares, H. (2010).  Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis.  BMC Cell Biology 11:40.  PMCID: PMC2891664
  4. Thompson, E. G., Schaheen, L., Dang, H., and Fares, H. (2007).  Lysosomal Trafficking Functions of mucolipin-1 in Murine Macrophages.  BMC Cell Biology 8:54. PMID: 18154673
  5. Schaheen, L., Patton, G., and Fares, H. (2006).  Suppression of the cup-5 Mucolipidosis Type IV-related lysosomal dysfunction by the inactivation of an ABC Transporter in C. elegans.  Development 133, 3939-3948. PMID: 16943270
  6. Schaheen, L., Dang, H., and Fares, H. (2006).  Basis of lethality in C. elegans lacking CUP-5, the Mucolipidosis Type IV orthologue. Developmental Biology 293, 382-391. PMID: 16530747
  7. Treusch, S., Knuth, S., Slaugenhaupt, S. A., Goldin, E., Grant, B. D., and Fares, H. (2004).  Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required  for lysosome biogenesis.  Proceedings of the National Academy of Science, USA 101,     4483-4488. PMID: 15070744

Professional Information

Other Experience and Professional Memberships/Affiliations: 

APPOINTMENTS

2013-present  Professor, Department of Molecular & Cellular Biology
2012-present  Associate Chair, Department of Molecular & Cellular Biology
2010-2012      Interim Chair, Dept. of Molecular and Cellular Biology
2007-2013      Associate Professor, Dept. of Molecular and Cellular Biology
2003-present   Joint faculty, Department of Cell Biology and Anatomy, University of Arizona
2001-present   Member, Arizona Cancer Center
2001-2007      Assistant Professor, Dept. of Molecular and Cellular Biology

Academic Information

Post Doctoral: 
Columbia University, New York
Doctorate: 
University of North Carolina, Chapel Hill
Master's Degree: 
University of Michigan, Ann Arbor
Undergraduate School: 
American University of Beirut, Lebanon