James M. Woolfenden, PhD

Professor Emeritus, Department of Medical Imaging

Phone Number: 
Short Bio: 

I have over 40 years of experience in clinical nuclear medicine, including service as Chief of Nuclear Medicine at the University of Arizona and Medical Director of Southwest PET/CT Institute.  I have been an investigator on NIH-funded research projects involving instrumentation development and both preclinical and clinical applications of radionuclide imaging since 1976.  My experience will be useful in the Center for Gamma-Ray Imaging in guiding instrumentation application and assessment in preclinical studies that have translational significance for important biomedical applications.

Research Information

Research Program: 
Cancer Imaging
Member Status: 
Associate Research Member
Selected Publications: 

Woolfenden JM, Hall JN, Barber HB, Wacks MG.  Samarium-153 citrate for tumor and abscess localization.  International Journal of Nuclear Medicine and Biology 10(4):251-256, 1983. PMID: 6582054

Barber HB, Barrett HH, Woolfenden JM, Meyers KJ, Hickernell TS. Comparison of in vivo scintillation probes and gamma cameras for detection of small, deep tumors. Phys Med Biol 34(6):727-739, 1989. PMID: 2740440

Hartsough NE, Barber HB, Woolfenden JM, Barrett HH, Hickernell TS, Kwo DP. Probes containing gamma radiation detectors for in vivo tumor detection and imaging. Proc SPIE 1068:92-99, 1989.

Woolfenden JM, Barber HB. Radiation detector probes for tumor localization using tumor-seeking radioactive tracers. Am J Roentgenol 153(1):35-39, 1989.  PMID: 2660536.

Rogulski MM, Barber HB, Barrett HH, Shoemaker RL, Woolfenden JM. Ultra-high-resolution SPECT: Simulation results. IEEE Trans Nucl Sci 1993;40:1123-1129.

Kastis GA, Barber HB, Barrett HH, Balzer SJ, Lu D, Marks DG, Stevenson G, Woolfenden JM, Appleby M, Tueller J. Gamma-ray imaging using a CdZnTe pixel array and a high-resolution, parallel-hole collimator. IEEE Trans Nucl Sci 47(6):1923-1927, 2000.

Kastis GA, Wu MC, Balzer SJ, Wilson DW, Furenlid LR, Stevenson G, Barber HB, Barrett HH, Woolfenden JM, Kelly P, Appleby M. Tomographic small-animal imaging using a high-resolution semiconductor camera. IEEE Trans Nucl Sci ;49(1):172-175, 2002.

Liu Z, Stevenson GD, Barrett HH, Kastis GA, Bettan M, Furenlid LR, Wilson DW, Woolfenden JM. Imaging recognition of multidrug resistance using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system. Nucl Med Biol 31(1):53-65, 2004.  PMCID: PMC3062994

Liu Z, Stevenson GD, Barrett HH, Furenlid LR, Wilson DW, Kastis GA, Bettan M, Woolfenden JM. Imaging recognition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin. Nucl Med Biol 32(6):573-583, 2005.  PMCID: PMC1402231

Kim H, Furenlid LR, Crawford MJ, Wilson DW, Barber HB, Peterson TE, Hunter WCJ, Liu Z, Woolfenden JM, Barrett HH.  SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) arrays. Med Phys 2006;33:465-475.

Liu Z, Barrett HH, Stevenson GD, Furenlid LR, Wilson DW, Woolfenden JM, Pak KY. Evaluating the protective role of ischemic preconditioning in rat hearts using a stationary small-animal SPECT imager and 99mTc-glucarate. Nucl Med Commun 29(2):120-128, 2008.  PMCID: PMC2586977

Liu Z, Chen L, Liu S, Barber C, Stevenson GD, Furenlid LR, Barrett HH, Woolfenden JM.  Kinetic characterization of a novel cationic 99mTc(I)-tricarbonyl complex, 99mTc-15C5-PNP, for myocardial perfusion imaging. J. Nucl Cardio 17(5): 858-867,2010.   PMC2940957

wyffels L, Gray BD, Barber C, Moore SK, Woolfenden JM, Pak KY, Liu Z.  Synthesis and preliminary evaluation of radiolabeled bis(zinc(II)-dipicolylamine) coordination complexes as cell death imaging agents.  Bioorganic & Medicinal Chemistry 19(11):3425-3433, 2011. PMC3102142

wyffels L, Gray BD, Barber C, Pak KY, Smith BD, Mattis JA, Woolfenden JM, Liu Z.  Detection of myocardial ischemia-reperfusion injury using a fluorescent near-infrared zinc(II)-dipicolylamine probe and 99mTc-glucarate.  Molecular Imaging 11(3):187-196, 2012. PMID: 22554483

Zhang Y, Stevenson GD, Barber C, Furenlid LR, Barrett HH, Woolfenden JM, Liu Z.  Imaging of rat cerebral ischemia-reperfusion injury using 99mTc-labeled duramycin.  Nucl Med Biol 40(1): 80-88, 2013.  PMC3632380

Professional Information

Board Certifications: 

American Board of Nuclear Medicine (1974)


1964                 Bachelor of Arts with Distinction, Stanford University

1964                 Elected to Phi Beta Kappa

1981                 Elected to Fellowship, American College of Nuclear Physicians

1997                 Elected to Life Membership, American Board of Nuclear Medicine

2009                 Elected to Fellowship, American College of Nuclear Medicine

1997-2008         Listed in Best Doctors in America

1996-present     Listed in Marquis’s Who’s Who in America

Academic Information

Nuclear Medicine, Los Angeles County/University of Southern California Medical Center (1972-74)
Medical School: 
University of Washington (1968)
Undergraduate School: 
Stanford University, B.A. with Distinction, Biological Sciences (1964)