Jean M. Wilson, PhD

Email Address: 
(520) 626-2097

Internal Contact Information

Professional Bio: 

Dr. Wilson is a Professor of Cellular and Molecular Medicine, a member of the Bio5 Institute and is affiliated with the Cancer Biology and Neuroscience Graduate Interdisciplinary Programs. Her research focuses on membrane trafficking in polarized cells, with an emphasis on how functional membrane domains are generated and maintained.  Using morphological, biochemical, and molecular biological approaches, she studies the mechanisms of biogenesis and targeting of endosomal proteins, polarized targeting of apical proteins, and trafficking of tight junction proteins. The role of membrane trafficking in the establishment and maintenance of epithelial polarity is a major point of emphasis. Loss of polarity is a hallmark of cancer, and current paradigms suggest that loss of polarity may be an early event in the transformation process. Her laboratory is working to define how membrane trafficking regulates morphogenesis, signaling, and fate in normal cells and how changes in these pathways could lead to cancer.

Research Information

Research Program: 
Cancer Biology
Member Status: 
Research Member
Selected Publications: 

Dr. Wilson's NCBI bibliography

  1. Wilson, J.M., J.A. Whitney, and M.R. Neutra. 1987. Identification of an endosomal antigen specific to absorptive cells of suckling rat ileum. J. Cell Biol. 105:691-703.
  2. Speelman B.A., K.A. Allen, M.R. Neutra, T. Kirchhausen, and J.M Wilson. 1995. Molecular characterization of an early endosomal glycoprotein found in developing rat intestine. J. Biol. Chem. 270:1583-1588.
  3. Wilson, J.M. and T.L. Colton. 1997. Targeting of an intestinal apical endosomal protein to endosomes in non-polarized cells. J. Cell Biol. 136:319-330.
  4. Hernandez-Deviez, D., J.E. Casanova, and J.M. Wilson. 2002. Regulation of dendritic development by the ARF exchange factor ARNO. Nature Neurosci. 5:623-624.
  5. Hernandez-Deviez, D., J.E. Casanova, Roth, M.G., and J. M. Wilson. 2004. ARNO and ARF6 regulate axonal elongation and branching through phosphatidylinositol 4-phosphate 5-kinase a. Mol. Biol. Cell 15:111-21.
  6. Kitt, K.N., D. Hernandez-Deviez, S. McCarter, E. Spiliotis, J.E. Casanova, and J.M. Wilson. 2008. The small GTPase Rab 14 regulates apical targeting. Traffic 9:1218-1231
  7. McCarter, S., D. Johnson, K.N. Kitt, C. Donohue, A.E. Adams and J.M. Wilson. 2010. Regulation of tight junction assembly and epithelial polarity by a resident protein of apical         endosomes. Traffic 11:856-866
  8. Parker, S.S., E.K. Mandell, S.M. Hapak, I.Y. Maskaykina,Y. Kusne, J.Y. Kim, J.K. Moy, P.A. St. John,   J.M. Wilson, K.M. Gothard, T.J. Price, S. Ghosh. 2013. Competing interactions of PKMζ          and aPKCλ with the Par complex regulates polarity. Proc Natl Acad Sci USA 110:14450-5. PMCID:PMC3761571
  9. Lu, R., D.L. Johnson, L. Stewart, K. Waite, and J.M. Wilson. 2014. Rab14 regulates epithelial lumen morphogenesis through regulation of claudin-2 trafficking. Mol Biol Cell 25:1744-54 PMCID: PMC4038501
  10. Lu, R, D. Dalgalan, E.K. Mandell, S.S. Parker, S. Ghosh and J.M. Wilson. 2015. PKCi interacts with Rab14 and regulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol Cell. 26(8):1523-31. doi: 10.1091/mbc.E14-12-1613. PMID:25694446
  11. Cox, C.M., Mandell, E.K., Stewart, L., Lu, R., Johnson, D.L., McCarter, S.D., Tavares, A., Runyan, R., Ghosh, S., Wilson, J.M. 2015. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Mol Biol Cell 26:2673-84. doi: 10.1091/mbc.E15-04-0224 PMID:25995376