Dr. Garcia is an authority on the genetic basis of inflammatory lung disease (with an emphasis on health disparities) and on the mechanistic basis of lung vascular permeability. Using bench-to-bedside approaches, his lab has explored novel methods to prevent vascular leak and to restore endothelial cell barrier function and vascular integrity. This expertise in lung inflammation and vascular permeability provides a natural linkage to interrogation of lung vascular contribution to the development of lung metastases.
Leveraging their genomic expertise, in recent years, Dr. Garcia's lab has identified vascular genes whose products are key participants in inflammatory lung injury that also play a role in cancer development. They have developed lung endothelial inflammatory gene expression profiles as well as diagnostic gene signatures influenced by MYLK and NAMPT that impact lung and breast cancer prognosis. This work with NAMPT led to development of a therapeutic NAMPT neutralizing antibody that has shown promise in treating lung cancer, melanoma, and chronic lymphocytic leukemia.
Finally, Dr. Garcia's lab is also interested in the untoward effect of thoracic radiation and has been examining strategies designed to attenuate radiation–induced pneumonits, fibrosis and vascular leak. These collaborative and highly translational cancer research efforts have bolstered the overall mission of the University of Arizona Cancer Center.
2014 - 2015 Interim Dean, College of Medicine, The University of Arizona
2013 - 2016 Senior Vice President for Health Sciences, The University of Arizona
2013 - current Dr. Merlin K. DuVal Professor of Medicine, University of Arizona
2010 - current Founder and President, Aqualung Therapeutics Corp.
2010 - 2013 Earl M. Bane Professor of Medicine, Pharmacology & Bioengineering, U. of Illinois, Chicago
2010 - 2012 Vice Chancellor for Research, University of Illinois at Chicago
2010 - 2012 Vice President for Health Affairs, University of Illinois
2005 - 2010 Dr. Lowell T. Coggeshall Professor & Chairman, Department of Medicine, Univ. of Chicago
1998 - 2005 Dr. David Marine Professor of Medicine, Biomedical Engineering & Environmental Health Sciences;
Director Division of Pulmonary & Critical Care Medicine, Johns Hopkins University
1992 - 1998 Dr. Calvin H. English Professor of Medicine, Physiology and Biophysics, Indiana University
1988 - 1992 Associate Professor of Medicine, Physiology and Biophysics, Indiana University
1985 - 1988 Assistant Professor of Medicine, University of Texas Health Center at Tyler, Texas
1984 - 1985 NIH Postdoctoral Fellow, Dept of Physiology, Albany Medical College, New York
1983 - 1984 Fellow, Division of Pulmonary Diseases, Albany Medical College, New York
1980 - 1983 Intern, Resident, Department of Internal Medicine, University of Iowa
2015 American Thoracic Society: Distinguished Leadership Award
2011 - current National Academy of Medicine (formerly the Institute of Medicine) National Academies (elected)
2009 Innovations in Diversity Award (Association of Professors in Medicine)
2005 - current Association of American Physicians (elected)
2004 - current Gordon Research Conference, Chair (2004, 2006): Endothelial Cell Phenotypes in Health & Disease
2004 - current American Clinical and Climatological Society (elected)
2003 - 2005 Howard Hughes Medical Institute Scientific Review Board
2003 - 2005 American Thoracic Society, Chair: Pulmonary Circulation Assembly (elected)
2003 American Thoracic Society: Distinguished Scientific Achievement Award
2002 David M. Levine Excellence in Mentoring Award, Johns Hopkins University, Department of Medicine
1999 - current Interurban Clinical Club (elected)
1996 - current American Society for Clinical Investigation (ASCI) (elected)
1996- 2007 Central Society for Clinical Research, Secretary-Treasurer, Councilor, President