Professor, Molecular and Cellular Biology
Our research focuses on understanding how cancer develops on a cellular level, and using that knowledge to develop highly specific and nontoxic treatments for cancer. My lab uses a variety of molecular and cellular techniques to understand how cancer cells grow, invade and usurp the body’s normal mechanisms for keeping cells under control. We have used this knowledge to develop peptide-based therapeutics that block tumor-specific interactions without affecting the biology of normal tissues.
Louderbough, J. M. V., Lopez, J. I., and Schroeder, J. A. Matrix Hyaluronan Alters Epidermal Growth Factor Receptor-Dependent Cell Morphology. Cell Adhesion and Migration,4:26-31, 2010. PMID: 20009574
Bitler, B. G. and Schroeder, J. A. Anti-Cancer Therapies that Utilize Cell Penetrating Peptides. Recent Patents on Anti-Cancer Drug Discovery, 5:99-108, 2010. PMID: 19961434
Bitler, B. G., Goverdhan, A. and Schroeder, J. A. MUC1 Regulates Nuclear Localization and Function of the Epidermal Growth Factor Receptor. Journal of Cell Science, 123:1716-1723, 2010. PMID: 20406885
Cheung, L. S. L., Zheng, X., Wang, L., Guzman, R., Schroeder, J. A., Heimark, R. L., Baygents, J. C., and Zohar, Y. Kinematics of specifically captured circulating tumor cells in bio-functionalized microchannels. Journal of Microelectromechanical Systems, 19:752-763, 2010.
Bitler BG, Schroeder JA. Dec 2009. Anti-Cancer Therapies that Utilize Cell Penetrating Peptides. Recent Pat Anticancer Drug Discov,2009 Dec 2;
Cheung LS, Zheng X, Stopa A, Baygents JC, Guzman R, Schroeder JA, Heimark RL, Zohar Y. Jun 2009. Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel. Lab Chip, 9:1721-31
Bitler BG, Menzl I, Huerta CL, Sands B, Knowlton W, Chang A, Schroeder JA. Jan 2009. Intracellular MUC1 peptides inhibit cancer progression. Clin Cancer Res, 15:100-9
Louderbough JM, Lopez JI, Schroeder JA. Jan 2009. Matrix hyaluronan alters epidermal growth factor receptor-dependent cell morphology. Cell Adh Migr,2009 Jan 29;4(1)
Pochampalli MR Bitler BG Schroeder JA. Jul 2007. Transforming growth factor alpha dependent cancer progression is modulated by Muc1. Cancer Res, 67:6591-8
Pochampalli MR Bejjani RM Schroeder JA. Sep 2006. MUC1 is a novel regulator of ErbB1 receptor trafficking. Oncogene,2006 Sep 18;
Lopez JI, Camenisch TD, Stevens MV, Sands BJ, McDonald J, Schroeder JA. Aug 2005. CD44 attenuates metastatic invasion during breast cancer progression. Cancer Res, 65:6755-63
2006, Sydney E. Salmon, M.D., Distinguished Junior Investigator, Arizona Cancer Center
2008, Galileo Circle Fellow, College of Science