Karen Taraszka Hastings, MD, PhD

Associate Professor, Basic Medical Sciences
Associate Professor, Immunobiology
Associate Professor, Cancer Biology - GIDP
Phone Number: 
(602) 827-2106
FAX: 
(602) 827-2127

UACC Information

UACC Organizational Unit(s): 
Professional Bio: 

Dr. Hastings is a physician-scientist with a research program that is focused on antigen processing and control of T cell-mediated responses with respect to tumor immunity and autoimmune disease. Her research expertise includes antigen processing and presentation, T cell tolerance, and regulatory T cells.  Her laboratory has defined gamma-interferon-inducible lysosomal thiol reductase (GILT) as a critical enzyme involved in the MHC class II-restricted presentation of and modulation of central and peripheral tolerance to melanocyte differentiation antigens, which are important in the immune recognition of melanoma and in vitiligo pathogenesis.

Dr. Hastings is also a practicing dermatologist and has ongoing collaborations investigating the clinical significance of GILT expression in melanoma and lymphoma.

Research Information

Research Program: 
Cancer Prevention and Control
Member Status: 
Research Member
Year of Membership Acceptance: 
2006
Research Focus: 
Dr. Hastings is a physician-scientist with a research program focused on antigen processing and control of T cell responses in skin cancer and autoimmunity. Her laboratory has defined gamma-interferon-inducible lysosomal thiol reductase (GILT) as a critical enzyme in MHC class II-restricted presentation of and regulation of T cell tolerance to melanocyte differentiation antigens important in melanoma and vitiligo. She is investigating the clinical significance of GILT in melanoma and lymphoma.
Selected Publications: 

Dr. Hastings' NCBI bibliography

  1. Nguyen J, Bernert R, In K, Kang P, Sebastiao N, Hu C, Hastings KT; Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma, Melanoma Research; 2016; 26(2):125-37.
  2. Rausch MP, Hastings KT; Diverse cellular and organismal functions of the lysosomal thiol reductase GILT, Molecular Immunology; 2015; 68(2 Pt A):124-8.
  3. Rausch MP, Hastings KT; An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen, PlosOne; 2015; 10(4):e0123332.
  4. Phipps-Yonas H, Cui H, Sebastiao N, Brunhoeber PS, Haddock E, Deymier MJ, Klapper W, Lybarger L, Roe DJ, Hastings KT; Low GILT expression is associated with poor survival in diffuse large B-cell lymphoma, Frontiers in Immunology; 2013; 4:425.
  5. Phipps-Yonas H, Semik V, Hastings KT; GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity, European Journal of Immunology; 2013; 43(1): 65-74.

Academic Information

Residency: 
Internal Medicine & Dermatology, Yale New Haven Hospital, New Haven, CT
Post Doctoral: 
Yale University
Doctorate: 
Immunology, Harvard Medical School, Boston, MA
Medical School: 
Harvard Medical School, Boston, MA
Undergraduate School: 
BS, Chemistry, Georgetown University, Washington, DC