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Dr. Hastings is a physician-scientist with a research program that is focused on antigen processing and control of T cell-mediated responses with respect to tumor immunity and autoimmune disease. Her research expertise includes antigen processing and presentation, T cell tolerance, and regulatory T cells. Her laboratory has defined gamma-interferon-inducible lysosomal thiol reductase (GILT) as a critical enzyme involved in the MHC class II-restricted presentation of and modulation of central and peripheral tolerance to melanocyte differentiation antigens, which are important in the immune recognition of melanoma and in vitiligo pathogenesis.
Dr. Hastings is also a practicing dermatologist and has ongoing collaborations investigating the clinical significance of GILT expression in melanoma and lymphoma.