Keith Maggert, PhD

Associate Professor, Cellular & Molecular Medicine
Associate Professor, Cancer Biology - GIDP
Associate Professor, Genetics - GIDP
Phone Number: 
(520) 626-9545

UACC Information

Professional Bio: 

Keith Maggert, PhD, a research scientist at the University of Arizona Cancer Center, has received a prestigious Transformative Research Award (TRA) and a five-year, $1.7 million grant from the National Institutes of Health (NIH) to fund his research program, “Induced Transgenerational Inheritance Without Epigenetics.” Investigators previously have attempted to use drugs that target epigenetics to treat diseases. Dr. Maggert’s work demonstrates why these treatments, in general, largely have been ineffective and in some cases even toxic. With the knowledge gained by this research, Dr. Maggert will seek to identify new and effective treatments for epigenetic diseases, such as cancer.

Clinical Information

Laboratory/Office: 

Research Information

Research Program: 
Cancer Biology
Member Status: 
Research Member
Year of Membership Acceptance: 
2016
Research Focus: 

Many cancer cells - as cause or consequence of their disease state - undergo hypermutation and genomic instability.  Dr. Maggert's laboratory is interested in how and why these events occur, and how they enable cancer development and progression.  They focus on the repetitive ribosomal RNA genes to understand how epigenetic inheritance, gene regulation, and genome stability are linked together such that defects in one result in defects in the others.

The Maggert Lab investigates how gene regulation is affected by chromosome structure and how gene expression influences genome stability. They have recently examined the impacts of rDNA copy number and its regulation in Drosophila melanogaster.

Selected Publications: 

2015

Aldrich, J. C., and K. A. Maggert, "Transgenerational inheritance of diet-induced genome rearrangements in Drosophila.", PLoS Genet, vol. 11, issue 4, pp. e1005148, 2015 Apr. PMCID: PMC4401788  PMID: 25885886
Deans, C., and K. A. Maggert, "What do you mean, "epigenetic"?", Genetics, vol. 199, issue 4, pp. 887-96, 2015 Apr. PMCID: PMC4391566  PMID: 25855649

2014

Aldrich, J. C., and K. A. Maggert, "Simple quantitative PCR approach to reveal naturally occurring and mutation-induced repetitive sequence variation on the Drosophila Y chromosome.", PLoS One, vol. 9, issue 10, pp. e109906, 2014. PMCID: PMC4186871  PMID: 25285439

2012

Maggert, K. A., "Genetics: polymorphisms, epigenetics, and something in between.", Genet Res Int, vol. 2012, pp. 867951, 2012. PMCID: PMC3335516  PMID: 22567405

2011

Paredes, S., A. T. Branco, D. L. Hartl, K. A. Maggert, and B. Lemos, "Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation.", PLoS Genet, vol. 7, issue 4, pp. e1001376, 2011 Apr. PMCID: PMC3080856  PMID: 21533076

Professional Information

Positions and Honors: 
High-Risk High-Reward Transformative Research Award National Institutes of Health, Office of the Director, Fall 2016

Academic Information

Doctorate: 
Biology, University of California San Diego, La Jolla, CA
Undergraduate School: 
BS, Biochemistry and Molecular Biology, University of California Santa Cruz, Santa Cruz, CA