Mark "Marty" Pagel, PhD

UA Associate (Chemistry & Biochemistry)
Email Address: 
Phone Number: 
( 713) 205-8515
Professional Bio: 

Dr. Marty Pagel earned his B.A. degrees in chemistry and biology at Washington University, St. Louis, MO, and then earned a Ph.D. degree in chemistry from the University of California Berkeley.  Dr. Pagel then worked as the director of the NMR and computational chemistry facilities in the Department of Chemistry at Indiana University.  He then joined Monsanto Co., which was acquired by Pharmacia Corp., which was then acquired by Pfizer Inc.  His research in industry involved the MR imaging of corn seeds and mouse models of breast cancer.  Dr. Pagel then returned to academia in 2003, when he joined the Department of Biomedical Engineering at Case Western Reserve University to start a research program in molecular imaging.  Dr. Pagel then moved to the University of Arizona in 2008 to expand his research program to include more chemistry development and clinical research. 

Dr. Pagel's research focuses on the measurement of tumor acidosis using non-invasive MRI.  His research program has refined this technique, termed “acidoCEST MRI” to measure acidosis in a variety of tumor models to study cancer biology and the effects of anti-cancer therapies.  They have also translated our acidoCEST MRI method to the clinic and we are measuring tumor acidosis levels in patients with breast, ovarian, lung and liver, and brain cancers.  Dr. Pagel's research program has also developed a MRI method that non-invasively detects enzyme activities in solid tumors.

Research Information

Selected Publications: 

Professional Information

Positions and Honors: 
Positions:
2016-2017      Director of the Contrast Agent Molecular Engineering Laboratory, University of Arizona, Tucson AZ
2015-2016      Director of Research and Program Development, Dept. of Medical Imaging, University of Arizona, Tucson AZ
2011-2017      Associate Professor, Dept. of Medical Imaging, U of Arizona, Tucson AZ
2010-2014      Assistant Department Head, Dept. of Biomedical Engineering, U of Arizona, Tucson AZ
2008-2017      Associate Professor, Dept. of Biomedical Engineering, Dept. of Chemistry & Biochemistry, U of Arizona, Tucson AZ
2007-2008      Chair, Institutional Animal Care and Use Committee, CWRU, Cleveland OH
2003-2008      Assistant Professor of Biomedical Engineering, Radiology, and Macromolecular Science & Engineering,
                         Case Western Reserve University, Cleveland, OH   
2001-2003      Senior Research Scientist, Pharmacia Corp., St. Louis, MO
2000-2001      Senior Research Scientist, Monsanto Company, St. Louis, MO
1997-2000      Associate Director of Technical Services, Chemistry, Indiana University, Bloomington, IN
1995-2000      Director of the NMR and Computational Chemistry Facilities, Indiana U., Bloomington, IN
1993-1995      Research Staff, NMR Facility, Chemistry, Indiana University, Bloomington, IN
 
Honors:
2014               Program Chair, World Molecular Imaging Congress, Seoul, Korea
2012               Arizona Engineering Faculty Fellow, University of Arizona, Tucson, AZ
2010-2014     Distinguished Reviewer, Magnetic Resonance in Medicine
2010               Sydney E. Salmon Junior Investigator Award, Arizona Cancer Center, Tucson AZ
2006               Case School of Engineering Graduate Teaching Award, CWRU, Cleveland, OH
2005               Young Investigator Award, Contrast Media Research 2005 Symposium
2003               Early Career Recognition Award, Pharmacia Corp., St. Louis, MO
1994               Department of Chemistry Staff Award, Indiana University, Bloomington, IN
1988               John C. Sowden Prize in Chemistry, Washington University, St. Louis, MO

Academic Information

Doctorate: 
University of California, Berkeley, 1993, Chemistry
Undergraduate School: 
BA, Chemistry & Biology, Washington University, St. Louis, MO