Professor, Biomedical Engineering
Associate Professor, Chemistry and Biochemistry
Associate Professor, BIO5 Institute
Dr. Marty Pagel earned his B.A. degrees in chemistry and biology at Washington University, St. Louis, MO, and then earned a Ph.D. degree in chemistry from the University of California Berkeley. Dr. Pagel then worked as the director of the NMR and computational chemistry facilities in the Department of Chemistry at Indiana University. He then joined Monsanto Co., which was acquired by Pharmacia Corp., which was then acquired by Pfizer Inc. His research in industry involved the MR imaging of corn seeds and mouse models of breast cancer. Dr. Pagel then returned to academia in 2003, when he joined the Department of Biomedical Engineering at Case Western Reserve University to start a research program in molecular imaging. Dr. Pagel then moved to the University of Arizona in 2008 to expand his research program to include more chemistry development and clinical research.
Dr. Pagel is an Associate Professor in Biomedical Imaging. He is a member of the Cancer Imaging Program of the University of Arizona Cancer Center (UACC), and the only member of this program who has laboratory space in the UACC buildings. He also serves as the Director of the Contrast Agent Molecular Engineering Laboratory (CAMEL) in the University of Arizona Cancer Center.
Dr. Pagel also serves as the Vice Chair of Research and Program Development and Chair of Cancer Imaging for the Department of Medical Imaging at the University of Arizona. These positions provide him with a unique ability to be a "bridge” that connects biomedical imaging researchers with other cancer researchers in the UACC, while also fostering the development of many pre-clinical and clinical cancer imaging collaborations within my research program.
Dr. Pagel's research focuses on the measurement of tumor acidosis using non-invasive MRI. His research program has refined this technique, termed “acidoCEST MRI” to measure acidosis in a variety of tumor models to study cancer biology and the effects of anti-cancer therapies. They have also translated our acidoCEST MRI method to the clinic and we are measuring tumor acidosis levels in patients with breast, ovarian, lung and liver, and brain cancers. Dr. Pagel's research program has also developed a MRI method that non-invasively detects enzyme activities in solid tumors. They also support projects that involve optical imaging and photoacoustic imaging for pre-clinical cancer studies.
5R01CA167183 (Pagel, PI) 04/01/12-02/28/16
Measuring Extracellular pH in Pre-clinical Tumor Models with CEST MRI
This proposal will develop CEST agents and improve CEST MRI methods that measure extracellular pH in the tumor microenvironment within pre-clinical cancer models.
2011-Present Associate Professor, Dept. of Medical Imaging, U of Arizona, Tucson AZ
2010-2014 Assistant Department Head, Dept. of Biomedical Engineering, U of Arizona, Tucson AZ
2008-Present Associate Professor, Dept. of Biomedical Engineering, Dept. of Chemistry & Biochemistry, U of Arizona, Tucson AZ
2007-2008 Chair, Institutional Animal Care and Use Committee, CWRU, Cleveland OH
2003-2008 Assistant Professor of Biomedical Engineering, Radiology, and Macromolecular Science & Engineering, Case Western Reserve University, Cleveland, OH
2001-2003 Senior Research Scientist, Pharmacia Corp., St. Louis, MO
2000-2001 Senior Research Scientist, Monsanto Company, St. Louis, MO
1997-2000 Associate Director of Technical Services, Chemistry, Indiana University, Bloomington, IN
1995-2000 Director of the NMR and Computational Chemistry Facilities, Indiana U., Bloomington, IN
1993-1995 Research Staff, NMR Facility, Chemistry, Indiana University, Bloomington, IN
2012 Arizona Engineering Faculty Fellow, University of Arizona, Tucson, AZ
2010-2014 Distinguished Reviewer, Magnetic Resonance in Medicine
2010 Sydney E. Salmon Junior Investigator Award, Arizona Cancer Center, Tucson AZ
2006 Case School of Engineering Graduate Teaching Award, CWRU, Cleveland, OH
2005 Young Investigator Award, Contrast Media Research 2005 Symposium
2003 Early Career Recognition Award, Pharmacia Corp., St. Louis, MO
1994 Department of Chemistry Staff Award, Indiana University, Bloomington, IN
1988 John C. Sowden Prize in Chemistry, Washington University, St. Louis, MO