Dr. Kiela has been involved in basic research on various aspects of the gut development, physiology, and pathophysiology for over eighteen years. His particular interest is in the therapeutic and pathophysiological aspects of Inflammatory Bowel Diseases. His laboratory is involved with pre-clinical studies on the effectiveness and mechanism of action of curcumin (a natural non-specific inhibitor of NF-kappa-B) in mouse models of CD and UC (chemically induced colitis and spontaneous colitis in IL-10 or TCR-alpha knockout mice); the role of NHE3, the major intestinal Na+/H+ exchanger, in the maintenance of epithelial integrity of the gut, and in modulation of the immune response in Inflammatory Bowel Diseases.
Dr. Kiela is also interested in the effects of acute and chronic colitis and inflammatory mediators on key players of systemic inorganic phosphate homeostasis, and its contribution to osteopenia and osteoporosis frequently associated with IBD.
Dr. Kiela's membership in the University of Arizona Cancer Center has opened up opportunities to contribute his expertise in collaborations with other members.
- R. Ramalingam, C. B. Larmonier, R. D. Thurston, M. T. Midura-Kiela, S-G. Zheng, F.K. Ghishan, and P. R. Kiela. Dendritic cell-specific disruption of TGFβ receptor II leads to altered regulatory T-cell phenotype and spontaneous multi-organ autoimmunity. J Immunol. 2012 Oct 15;189(8):3878-93. PMCID: PMC3466393.
- Q. Lan , X. Zhou , M. Chen , J. Wang , H. Fan , B. Ryffel , D. Brand , R. Ramalingam , P.R. Kiela , D. Horwitz, Z. Liu. SG Zheng. Polyclonal CD4+Foxp3+ T cells generated ex-vivo induce TGFβ, but not IL-10-dependent tolerogenic dendritic cells that suppress murine lupus-like syndrome. Journal of Molecular Cell Biology 2012 Dec;4(6):409-19. PMCID: PMC3523557.
- McFadden R-M T, Larmonier CB, Shehab KW, Midura-Kiela M, Ramalingam R, Harrison CA, Besselsen DG, Chase JH, Caporaso JG, Jobin C, Ghishan FK, and Kiela PR. The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention. Inflammatory Bowel Diseases; 2015 (In Print)
- Radhakrishnan VM, Kojs P, Young G, Ramalingam R, Jagadish B, Mash EA, Martinez JD, Ghishan FK, Kiela PR. pTyr421 Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1). PLoS One. 2014 Jan 22;9(1):e85796. PMCID: PMC3899080.
- Midura-Kiela MT, Radhakrishnan VM, Larmonier CB, Laubitz D, Ghishan FK, Kiela P.R. Curcumin inhibits interferon gamma signaling in colonic epithelial cells. American Journal of Physiology Gastrointestinal and Liver Physiology. 2012 Jan;302(1):G85-96. PMCID: PMC3345961.
- C.B. Larmonier, M.T. Midura-Kiela, R. Ramalingam, D. Laubitz, N. Larmonier, F.K. Ghishan, and P.R. Kiela. Modulation of Neutrophil Recruitment by Curcumin: Relevance for Inflammatory Bowel Diseases. Inflammatory Bowel Diseases; 2011 Feb;17(2):503-15. PMCID: PMC2958245.
- Larmonier CB, Laubitz D, Hill FM, Shehab KW, Lipinski L, Midura-Kiela MT, McFadden RM, Ramalingam R, Hassan KA, Golebiewski M, Besselsen DG, Ghishan FK, Kiela PR. Reduced Colonic Microbial Diversity is Associated with Colitis in NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15;305(10):G667-77. PMCID: PMC3840234.
- Larmonier CB, Laubitz D, Thurston RD, Bucknam AL, Hill FM, Midura-Kiela MT, Ramalingam R, Kiela P.R.*, Ghishan FK*. NHE3 modulates the severity of colitis in IL-10-deficient mice. American Journal of Physiology Gastrointestinal and Liver Physiology. 2011 300:G998-G1009. PMCID: PMC3119112 * shared senior authorship
- Kiela P.R., Laubitz D, Larmonier CB, Midura-Kiela MT, Lipko MA, Janikashvili N, Bai A, Thurston R, Ghishan FK. Changes in mucosal homeostasis predispose NHE3 knockout mice to increased susceptibility to DSS-induced epithelial injury. Gastroenterology. 2009, 137(3):965-75. PMCID: PMC3454522.
- V.M. Radhakrishnan, R.D. Thurston, C.B. Larmonier, R. Ramalingam, D. Laubitz, P.R. Kiela, and F.K. Ghishan. Bone loss and renal Ca2+ wasting in experimental colitis is accompanied by downregulation of TRPV5 in renal distal convoluted tubules. Gastroenterology, 2013 Sep;145(3):613-24 (featured article)
- C.B. Larmonier, R-M. T. McFadden, F. M. Hill, R. Schreiner, R. Ramalingam, D.G. Besselsen, F.K. Ghishan, and P.R. Kiela. High Vitamin D diet administered during active colitis negatively affects bone metabolism in adoptive T-cell transfer model. American Journal of Physiology Gastrointestinal and Liver Physiology. 2013 Jul 1;305(1):G35-46. PMCID: PMC3725694.
- Thurston RD, Larmonier CB, Majewski PM, Ramalingam R, Midura-Kiela M, Laubitz D, Vandewalle A, Besselsen DG, Mühlbauer M, Jobin C, Kiela P.R.*, Ghishan FK*. Downregulation of aging-related Klotho gene in experimental colitis: the role of TNF and IFN-gamma. Gastroenterology. 2010 Apr;138(4):1384-94. PMCID: PMC3454518 * shared senior authorship
- Majewski PM, Thurston RD, Ramalingam R, Kiela P.R.*, Ghishan FK*. Cooperative role of NF-κB and Poly(ADP ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of Phex expression in osteoblasts. Journal of Biological Chemistry. 2010 Nov 5;285(45):34828-33. PMCID: PMC2966098 * shared senior authorship
2011-2016 Fixed term appointment as a faculty member of the Graduate School at the University of North Carolina at Chapel Hill (as a mentor to one PhD student who completed her PhD thesis in my lab. Currently inactive).
2007-Present Associate Professor, Department of Immunobiology, University of Arizona, Tucson, AZ. Member of the Molecular Pathogenesis Faculty of the Immunobiology Graduate Program.
2006-Present Associate Professor, Section of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Arizona, Tucson, AZ (tenured in 2012)
2001-2006 Assistant Professor, Section of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Arizona, Tucson, AZ
2000-2001 Research Assistant Scientist, Section of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Arizona, Tucson, AZ
2011 Nominated for “Outstanding UBRP Faculty Mentor” in recognition of mentoring undergraduate student members of the University of Arizona Undergraduate Research Program (honorable mention)
2009-Present Editorial Board Member of World Journal of Gastrointestinal Pathophysiology (WJGP) (a new monthly open-access peer-reviewed journal)
2009-Present Editorial Board Member & Section Editor for Inflammatory Bowel Diseases (Cell Biology/Biochemistry/Molecular Biology)
2007-2014 Session chair for various DDW sessions, e.g. “Mechanisms, consequences and preclinical treatment of intestinal inflammation”, “Inflammatory cytokines in IBD pathogenesis and treatment”
1993 Training Scholarship at the Institute for Animal Physiology, Rakuno Gakuen University, Ebetsu, Japan
1990-1994 Merit Scholarship for outstanding achievements as a student of the School of Veterinary Medicine