Pawel R Kiela, DVM, PhD

Associate Professor
Email Address: 
Phone Number: 
(520) 626-9687

UACC Information

UACC Organizational Unit: 
Professional Bio: 

Dr. Kiela has been involved in basic research on various aspects of the gut development, physiology, and pathophysiology for over eighteen years. His particular interest is in the therapeutic and pathophysiological aspects of Inflammatory Bowel Diseases.  His laboratory is involved with pre-clinical studies on the effectiveness and mechanism of action of curcumin (a natural non-specific inhibitor of NF-kappa-B) in mouse models of CD and UC (chemically induced colitis and spontaneous colitis in IL-10 or TCR-alpha knockout mice); the role of NHE3, the major intestinal Na+/H+ exchanger, in the maintenance of epithelial integrity of the gut, and in modulation of the immune response in Inflammatory Bowel Diseases. 

Dr. Kiela is also interested in the effects of acute and chronic colitis and inflammatory mediators on key players of systemic inorganic phosphate homeostasis, and its contribution to osteopenia and osteoporosis frequently associated with IBD. 

Dr. Kiela's membership in the University of Arizona Cancer Center has opened up opportunities to contribute his expertise in collaborations with other members.

Research Information

Research Program: 
Cancer Biology
Member Status: 
Research Member
Year of Membership Acceptance: 
Selected Publications: 

Dr. Kiela's NCBI bibliography

  1. R. Ramalingam, C. B. Larmonier, R. D. Thurston, M. T. Midura-Kiela, S-G. Zheng, F.K. Ghishan, and P. R. Kiela. Dendritic cell-specific disruption of TGFβ receptor II leads to altered regulatory T-cell phenotype and spontaneous multi-organ autoimmunity. J Immunol. 2012 Oct 15;189(8):3878-93. PMCID: PMC3466393.
  2. Q. Lan , X. Zhou , M. Chen , J. Wang , H. Fan , B. Ryffel , D. Brand , R. Ramalingam , P.R. Kiela , D. Horwitz, Z. Liu. SG Zheng. Polyclonal CD4+Foxp3+ T cells generated ex-vivo induce TGFβ, but not IL-10-dependent tolerogenic dendritic cells that suppress murine lupus-like syndrome. Journal of Molecular Cell Biology 2012 Dec;4(6):409-19. PMCID: PMC3523557.
  3. McFadden R-M T, Larmonier CB, Shehab KW, Midura-Kiela M, Ramalingam R, Harrison CA, Besselsen DG, Chase JH, Caporaso JG, Jobin C, Ghishan FK, and Kiela PR. The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention. Inflammatory Bowel Diseases; 2015 (In Print)
  4. Radhakrishnan VM, Kojs P, Young G, Ramalingam R, Jagadish B, Mash EA, Martinez JD, Ghishan FK, Kiela PR. pTyr421 Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1). PLoS One. 2014 Jan 22;9(1):e85796. PMCID: PMC3899080.
  5. Midura-Kiela MT, Radhakrishnan VM, Larmonier CB, Laubitz D, Ghishan FK, Kiela P.R. Curcumin inhibits interferon gamma signaling in colonic epithelial cells. American Journal of Physiology Gastrointestinal and Liver Physiology. 2012 Jan;302(1):G85-96. PMCID: PMC3345961.
  6. C.B. Larmonier, M.T. Midura-Kiela, R. Ramalingam, D. Laubitz,  N. Larmonier, F.K. Ghishan, and P.R. Kiela. Modulation of Neutrophil Recruitment by Curcumin: Relevance for Inflammatory Bowel Diseases. Inflammatory Bowel Diseases;  2011 Feb;17(2):503-15. PMCID: PMC2958245.
  7. Larmonier CB, Laubitz D, Hill FM, Shehab KW, Lipinski L, Midura-Kiela MT, McFadden RM, Ramalingam R, Hassan KA, Golebiewski M, Besselsen DG, Ghishan FK, Kiela PR. Reduced Colonic Microbial Diversity is Associated with Colitis in NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15;305(10):G667-77. PMCID: PMC3840234.
  8. Larmonier CB, Laubitz D, Thurston RD, Bucknam AL, Hill FM, Midura-Kiela MT, Ramalingam R, Kiela P.R.*, Ghishan FK*. NHE3 modulates the severity of colitis in IL-10-deficient mice. American Journal of Physiology Gastrointestinal and Liver Physiology. 2011 300:G998-G1009. PMCID: PMC3119112 * shared senior authorship
  9. Kiela P.R., Laubitz D, Larmonier CB, Midura-Kiela MT, Lipko MA, Janikashvili N, Bai A, Thurston R, Ghishan FK. Changes in mucosal homeostasis predispose NHE3 knockout mice to increased susceptibility to DSS-induced epithelial injury. Gastroenterology. 2009, 137(3):965-75. PMCID: PMC3454522.
  10. V.M. Radhakrishnan, R.D. Thurston, C.B. Larmonier, R. Ramalingam, D. Laubitz, P.R. Kiela, and F.K. Ghishan. Bone loss and renal Ca2+ wasting in experimental colitis is accompanied by downregulation of TRPV5 in renal distal convoluted tubules.  Gastroenterology, 2013 Sep;145(3):613-24 (featured article)
  11. C.B. Larmonier, R-M. T. McFadden, F. M. Hill, R. Schreiner, R. Ramalingam, D.G. Besselsen, F.K. Ghishan, and P.R. Kiela. High Vitamin D diet administered during active colitis negatively affects bone metabolism in adoptive T-cell transfer model. American Journal of Physiology Gastrointestinal and Liver Physiology. 2013 Jul 1;305(1):G35-46. PMCID: PMC3725694.
  12. Thurston RD, Larmonier CB, Majewski PM, Ramalingam R, Midura-Kiela M, Laubitz D, Vandewalle A, Besselsen DG, Mühlbauer M, Jobin C, Kiela P.R.*, Ghishan FK*. Downregulation of aging-related Klotho gene in experimental colitis: the role of TNF and IFN-gamma. Gastroenterology. 2010 Apr;138(4):1384-94. PMCID: PMC3454518 * shared senior authorship
  13. Majewski PM, Thurston RD, Ramalingam R, Kiela P.R.*, Ghishan FK*. Cooperative role of NF-κB and Poly(ADP ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of Phex expression in osteoblasts. Journal of Biological Chemistry. 2010 Nov 5;285(45):34828-33. PMCID: PMC2966098 * shared senior authorship
Collaborative Research: 
5R01 DK041274-28    (Ghishan/Kiela. MPI)                                       09/01/88-08/31/17
Development of Intestinal Ion Transport
This proposal is designed to continue studies on NHE3-mediated Na+/H+ exchange in epithelial cell homeostasis and barrier function during health and disease states. There is no overlap with the proposed project
Role: MPI
5R37 DK33209-33      (Ghishan, PI)                                                   12/01/83 – 02/28/18
Development of Intestinal Transport of Ca++ and Pi
The major goal of this project is to determine the effects of inflammatory bowel disease on systemic phosphate and calcium homeostasis and its key regulatory elements related to intestinal, renal and skeletal handling as it relates to decreased bone mass in IBD patients. There is no overlap with the proposed project.
Role: Co-Investigator
5R01 DK067286-09    (Kiela/Ghishan, MPI)                                      11/01/03 – 04/30/14
Intestinal Barrier Function: Protective Effects of Curcumin
This proposal is focused on a clinically relevant aspect of numerous intestinal and extraintestinal disorders initiated or exacerbated by a dysfunction or failure of the intestinal epithelial barrier
Role: PI

Professional Information

Positions and Honors: 
2011-Present       Member of the Nutritional Sciences Graduate Program, University of Arizona.
2011-2016           Fixed term appointment as a faculty member of the Graduate School at the University of North Carolina at Chapel Hill (as a mentor to one PhD student who completed her PhD thesis in my lab. Currently inactive).
2007-Present        Associate Professor, Department of Immunobiology, University of Arizona, Tucson, AZ. Member of the Molecular Pathogenesis Faculty of the Immunobiology Graduate Program.
2006-Present        Associate Professor, Section of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Arizona, Tucson, AZ (tenured in 2012)
2001-2006           Assistant Professor, Section of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Arizona, Tucson, AZ
2000-2001           Research Assistant Scientist, Section of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Arizona, Tucson, AZ
2011, 2013, 2014 Nominated for Vernon and Virginia Furrow Award for Excellence in Graduate Student Education
2011                     Nominated for “Outstanding UBRP Faculty Mentor” in recognition of mentoring undergraduate student members of the University of Arizona Undergraduate Research Program (honorable mention)
2009-Present        Editorial Board Member of World Journal of Gastrointestinal Pathophysiology (WJGP) (a new monthly open-access peer-reviewed journal)
2009-Present        Editorial Board Member & Section Editor for Inflammatory Bowel Diseases (Cell Biology/Biochemistry/Molecular Biology)
2007-2014           Session chair for various DDW sessions, e.g. “Mechanisms, consequences and preclinical treatment of intestinal inflammation”, “Inflammatory cytokines in IBD pathogenesis and treatment”
1993                     Training Scholarship at the Institute for Animal Physiology, Rakuno Gakuen University, Ebetsu, Japan
1990-1994           Merit Scholarship for outstanding achievements as a student of the School of Veterinary Medicine

Academic Information

Post Doctoral: 
University of Arizona, Tucson, AZ
School of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland
Medical School: 
DVM, School of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland