Phillip H Kuo, MD, PhD

Professor of Medical Imaging 
Departments of Medicine and Biomedical Engineering
Section Chief of Nuclear Medicine
Email Address: 

UACC Information

UACC Organizational Unit: 
Professional Bio: 

For many years, Dr. Kuo has worked closely with the University of Arizona Cancer Center members, Marty Pagel and Amanda Baker, to develop acidoCEST MRI for pre-clinical studies. More recently, they have collaborated to develop clinical acidoCEST MRI, SAFARI “direct-CEST” MRI, and QUESPOWR “reverse-CEST” MRI at the University of Arizona.

Dr. Kuo's background as a clinical radiologist and physician scientist provides him the experience to move forward with translational research. This has required joint efforts to obtain approval from their institution’s IRB for clinical research, combined efforts to arrange for commercial contrast agents from several companies, and many team meetings to organize the logistics and protocols for performing clinical research studies that involve the injection of a contrast agent. For example specifically, Dr. Kuo is the principal investigator on the Institutional Review Board approved protocol for the use of CEST on normal volunteers and patients. He looks forward to helping his collaborators understand the intricacies of the regulatory issues for clinical trials as well as the myriad other aspects for running a successful trial.

Specialty: 
Medical Imaging

Clinical Information

Disease or Clinical Specialty: 
Medical Imaging

Research Information

Research Program: 
Cancer Imaging
Member Status: 
Research Member
Year of Membership Acceptance: 
2008
Summary of Research Activity: 
Contrast agent development, theranostics, PET/CT, SPECT/CT, magnetic resonance imaging (in particular CEST), and brain imaging.
Selected Publications: 
  1. Ho A, Avery R, Krupinski E, Warneke J and Kuo PH: Predictive Role of Imaging in Sentinel Lymph Node Dissection for Melanoma. Lymphology; 2014; 47(3): 134-141.
  2. Chen LQ, Howison C, Jeffrey J, Robey I, Kuo PH and Pagel M: Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI. Magnetic Resonance in Medicine. 2014, 72(5): 1408-17.
  3. Kuo PH, Nauman RW, Symanowski J, Nguyen B, Harb W and Edelman MJ: 99mTc-etarfolatide (EC20) SPECT imaging for the identification of ovarian and non-small cell lung cancer (NSCLC) patients who are most likely to benefit from folate-receptor targeted agent vintafolide (EC145). Journal of Nuclear Medicine, February 2013; 54(2S): 14.
  4. Goldberg MR and Kuo PH. Thrombus presents as palpable breast mass. The Breast Journal, 2011, 17(5), 561–563.
  5. Kuo PH, Thompson K, Christensen I, Girardi M, and Heald PW. (Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography) FDG-PET/CT for the Evaluation of Response to Therapy of Cutaneous T-cell Lymphoma to Suberoylanilide Hydroxamic Acid in a Phase II Trial. Molecular Imaging and Biology. Nov-Dec 2008, 10(6):306-14.
  6. Kuo PH, Chen Z, and Weidhaas J. (Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography) FDG-PET/CT for the Optimization of Planning of Radiation Therapy. Applied Radiology. Aug 2008: 1-23.
  7. Kuo PH, McClennan BL, Thompson K, Wilson LD, Edelson RL, Heald PW, and Girardi M. (2008) FDG-PET/CT in the Evaluation of Cutaneous T-cell Lymphoma. Molecular Imaging and Biology. 10(2):74-81.
  8. Kuo PH, Kanal E, Abu-Alfa A, and Cowper S. (2007) Gadolinium-Based MRI Contrast Agents and Nephrogenic Systemic Fibrosis. Radiology 242(3): 647-9.
  9. Kuo PH and Shin MS. (2007) Pulmonary and Peritoneal Ossification. New England Journal of Medicine 356(17): e16.
  10. Rye RO, Kuo PH, Holland HD. (1995) Atmospheric carbon dioxide concentrations before 2.2 billion years ago. Nature 378: 603-605.
Collaborative Research: 
Ongoing:
5R01CA167183                      (Pagel, PI)                                                                                 04/01/12-02/28/16
NIH/NCI          
Measuring Extracellular pH in Pre-clinical Tumor Models with CEST MRI
This proposal will develop CEST agents and improve CEST MRI methods that detect enzyme activities in pre-clinical cancer models.
Role: Co-investigator
 
5R01CA169774-01                 (Pagel, PI)                                                                                07/01/12-05/31/17
NIH/NCI
Detection of in vivo Enzyme Sctivities with CEST MRI
This proposal will develop CEST agents and improve CEST MRI methods that detect enzyme activities in pre-clinical cancer models.
Role: Co-investigator
 
Completed:
No Grant #                              (Persky, PI)                                                                              01/01/15 - 06/30/15  
American Chemical Society 
Exploring the Feasibility of AcidoCEST MRI to Investigate the Lymphoma Microenvironment
The proposed research applies our clinical acidoCEST MRI method to evaluate the extracellular pH in solid tumors to improve the diagnosis and early assessments of chemotherapies in patients with lymphoma.      
Role: Co-investigator
 
5R42NS055475                       (Kuo, PI)                                                                                  09/01/13 – 08/31/15
NIH/NINDS
Computational Tools for Research in Neuroscience, Behavioral Science and Mental Health.
Terminated early due to primary awardee's Small Business restructuring.
Role: Sub-Award Principal Investigator

Professional Information

Positions and Honors: 
Positions:
2015-Present   Professor with tenure, Departments of Medical Imaging and Biomedical Engineering, Section Chief of Nuclear Medicine and Director of PET/CT, Department of Medical Imaging, University of Arizona School of Medicine, Tucson, Arizona
2010-2014      Associate Professor, Departments of Medical Imaging, Medicine and Biomedical Engineering, Section Chief of Nuclear Medicine and Director of PET/CT, Department of Medical Imaging, University of Arizona School of Medicine, Tucson, Arizona
2008-2010      Clinical Director of Breast Imaging and Associate Section Head of Nuclear Medicine, Southern Arizona Veterans Administration Hospital, Tucson, AZ
2008-2010      Associate Professor, Department of Medicine, Section of Hematology-Oncology, University of Arizona School of Medicine, Tucson, Arizona
2005-2008      Assistant Clinical Professor, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT
2004-2005      Clinical Instructor, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT
 
Honors:
2014             Promotion to Full Professor with tenure
2014             Instructor for the American College of Radiology PET/CT Course (Reston, VA)
2014            Grand Saguaro Award for Teaching of Medical Students
2014             Featured lecturer at the Etarfolatide European Expert Faculty Meeting at the Old Stock Exchange in Amsterdam, Netherlands. Lectured to over 30 nuclear medicine experts from across Europe.
2014             #1 and #5 Most-Cited Articles from last 2 years as of September 1, 2014 for Journal of Nuclear Medicine Technology
2013             SAM-CME Course Instructor for Dopamine Transporter Imaging at the Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (Vancouver, Canada)
2013             Primary sponsor for Capstone senior project in Engineering: Motion Correction for PET and SPECT Using Wearable Sensors
2013             Plenary session talk at the AACR-SNMMI State-of-the-Art Molecular Imaging in Cancer Biology and Therapy Joint Conference (San Diego, CA)
2013             Member of expert panel for white paper on “Efficient and Effective Diagnosis of Parkinson’s Disease: Guidance for Managed Care” (Miami, FL)
2013             Instructor for the American College of Radiology PET/CT Course (Reston, VA)
2013             Course Instructor for Molecular Neuroimaging at the Annual Meeting of the American Roentgen Ray Society (Washington, DC)
2012             Steering Committee for Endocyte’s development of targeted folate receptor imaging
2010             Medical Advisory Council to the Global Fibrosis Foundation
2010             Co-Director of Research Education for the Arizona Cancer Center
2009            Medscape’s Top 10 Most Read Articles by Radiologists July 2009.
2009             Medscape’s #1 full-text journal article read by radiologists July 2009. Kuo PH, Abu-Alfa A, Bucala R, , Griffith J, Thompson K, Girardi M, Weinreb J, Cowper SE.  MRI with Gadolinium-based Contrast Agents in the Era of Nephrogenic Systemic Fibrosis: Review, Controversies, and Suggested Protocols. Applied Radiology. April 2009, 38(4): 22-33.
2008             Guest Editor for special issue of the Journal of the American College of Radiology entitled “Nephrogenic Systemic Fibrosis and MRI Contrast”
2008             Cover article for Applied Radiology Aug 2008
2006             Award for Education Exhibit: Kuo PH and Weidhaas J. “Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography (FDG-PET/CT) for the Optimization of Planning of Radiation Therapy”, Annual Meeting of the Radiological Society of North America, Chicago, IL.
2000             Society of Fellows, Representative for the School of Medicine (University of Virginia)
1994-2000   Medical Scientist Training Program Fellowship (University of Virginia)
1990-1994   Dean’s List Harvard University
Other Experience and Professional Memberships/Affiliations: 
2011   Member of the Southwest Oncology Group (SWOG)   
2010   Member of Medical Advisory Council to the Global Fibrosis Foundation
2010   Member of the American Roentgen Ray Society
2009   Reviewer for Investigative Radiology
2009   Reviewer for American Journal of Roentgenology
2008   Reviewer for Molecular Imaging and Biology
2008   Reviewer for European Radiology
2008   Full Member of the Arizona Cancer Center
2008   Diplomate of the American Board of Radiology
2008   Reviewer for Nature Medicine
2006   Diplomate of the Certification Board of Nuclear Cardiology
2006   Advisory Panel to FDA on Association of Gadolinium-Based MRI Contrast with Nephrogenic Systemic Fibrosis
2005   Member of the Radiological Society of North America
2004   Diplomate of the American Board of Nuclear Medicine
2003   Diplomate of the American Board of Internal Medicine
Board Certifications: 
2009 - Medical Board of Arizona Licensure
2008 - American Board of Radiology
2006 - Board of Nuclear Cardiology
2004 - American Board of Nuclear Medicine
2003 - American Board of Internal Medicine
2003 - Medical Board of Connecticut Medical Licensure
4/01 - USMLE Step 3
2/00 - USMLE Step 2
6/96 - USMLE Step 1 – 99th percentile

Academic Information

Fellowship: 
Yale New Haven Hospital, New Haven, Conn., Nuclear Medicine
Residency: 
Yale New Haven Hospital, New Haven, Conn., Diagnostic Radiology; UCLA Medical Center, Los Angeles, Calif., Internal Medicine
Medical School: 
University of Virginia School of Medicine, Charlottesville, Va., 2000
Master's Degree: 
University of Virginia School of Medicine, Charlottesville, Va., Molecular Physiology and Biological Physics, 1998
Undergraduate School: 
Harvard University, Cambridge, Mass., AB Chemistry, 1994