Qin M Chen, PhD

Associate, Center for Toxicology
Professor, Applied BioSciences - GIDP
Professor, Cancer Biology - GIDP
Professor, Pharmacology
Professor, Pharmacology and Toxicology
Email Address: 
Phone Number: 
(520) 626-9126

UACC Information

UACC Organizational Unit(s): 
Professional Bio: 

Dr. Chen's leadership roles include directing NIEHS training program at the University of Arizona for 12 years, coordinating and teaching a large undergraduate course in pharmacology, and interacting with physicians worldwide to develop translational research projects.  Under her leadership, the training program has gained yearly trainee positions from 9 to 12, operated with transparency, established External Advisory Board, supported students through University wide selection, balanced the number of trainees per laboratory, fostered training of leadership skills, and supported 45 predoctoral students and 15 postdoctoral fellows.  

Dr. Chen's laboratory has been focused on studying the molecular biology of oxidative stress, and she has 15 years of experience in utilizing genomic and proteomic technology to address basic science questions.  She has trained 14 postdoctoral fellows, 11 Ph.D. and 4 M.S students. Ongoing research projects in her laboratory include 1) stress induced de novo protein synthesis for organ protection; 2) role of Nrf2 transcription factor in protection against cardiac injury; 3) function of Glucocorticoid Induced Leucine Zipper in the myocardium; 4) pharmacological agents that protect the heart from ischemic and chemotherapeutic injuries; and 5) biomarker discovery for predicting tissue injury due to oxidative stress.

Dr. Chen’s laboratory has well-established expertise in cell biology, molecular biology and animal models of oxidative stress. Her membership at the University of Arizona Cancer Center has brought new opportunities for collaboration in the area of cancer research.

Research Information

Research Program: 
Cancer Biology
Member Status: 
Research Member
Year of Membership Acceptance: 
2010
Summary of Research Activity: 
Molecular Biology of Oxidative Stress, Stress Hormones, Mechanism of Protein Translation under Stress Conditions, Nrf2 Transcription factor,  Cytoprotection, Cardiac Protection, Biomarkers of cardiac injury
Selected Publications: 
  1. Lee, S. C., Zhang, J., Strom, J., Yang, D., Dinh, T. N., Kappeler, K., & Chen, Q. M. (2017). G-Quadruplex in the NRF2 mRNA 5' Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress. Molecular and cellular biology, 37(1).
  2. Chen, Q., & Alpert, J. S. (2016). Nutraceuticals: Beneficial in Clinical Practice. American Journal of Medicine.
  3. Chen, Q., & Alpert, J. S. (2016). To Sup or Not to Sup: Is There Any Role of Antioxidant Vitamins in the Management of Heart Failure?. American Journal of Medicine.
  4. Morrissy, S. J., Sun, H., Zhang, J., Strom, J., & Chen, Q. M. (2016). Differential Regulation of Bcl-xL Gene Expression by Corticosterone, Progesterone, and Retinoic Acid. Journal of biochemical and molecular toxicology.
  5. Strom, J., Xu, B., Tian, X., & Chen, Q. M. (2015). Nrf2 protects mitochondrial decay by oxidative stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
  6. Aguilar, D., Strom, J., & Chen, Q. M. (2014). Glucocorticoid induced leucine zipper inhibits apoptosis of cardiomyocytes by doxorubicin. Toxicology and applied pharmacology, 276(1), 55-62.
  7. Strom, J., Swyers, T., Wilson, D., Unger, E., Chen, Q. M., & Larson, D. F. (2014). Dodecafluoropentane emulsion elicits cardiac protection against myocardial infarction through an ATP-Sensitive K+ channel dependent mechanism. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy, 28(6), 541-7.
  8. Xu, B., Zhang, J., Strom, J., Lee, S., & Chen, Q. M. (2014). Myocardial ischemic reperfusion induces de novo Nrf2 protein translation. Biochimica et biophysica acta, 1842(9), 1638-47.
  9. Chen, Q., Zhang, J., & Chen, Q. (2013). Far upstream element binding protein 1: a commander of transcription, translation and beyond. Oncogene, 32(24).
  10. Chen, Y., Aguilar, D. C., Strom, J., Xu, B., Kappeler, K., & Chen, Q. (2013). Expression of glucocorticoid-induced leucine zipper (GILZ) in cardiomyocytes. Cardiovascular toxicology, 13(2).
  11. Alpert, J. S., & Chen, Q. M. (2012). Has the genomic revolution failed?. Clinical cardiology, 35(3), 178-9.
  12. Alpert, J. S., & Chen, Q. M. (2012). Modern medicine and the Garden of Eden. The American journal of medicine, 125(11), 1043-4.
  13. Alpert, J. S., & Chen, Q. M. (2012). So, you want to live to 120? The genie in the bottle. The American journal of medicine, 125(7), 621-2.
  14. Chen, Y., Kappeler, K. V., Zhang, J., Dinh, T. N., Strom, J. G., & Chen, Q. (2012). Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress. Toxicological sciences : an official journal of the Society of Toxicology, 127(1).
  15. Chen, Y., Morrissy, S., Strom, J., Purdom-Dickinson, S., & Chen, Q. (2012). NAD(P)H:quinone oxidoreductase 1 is induced by progesterone in cardiomyocytes. Cardiovascular toxicology, 12(2).
  16. Chen, Y., Zhang, J., Dinh, T. N., Kappeler, K., Tsaprailis, G., & Chen, Q. (2012). La autoantigen mediates oxidant induced de novo Nrf2 protein translation. Molecular & cellular proteomics : MCP, 11(6).
  17. Chen, Y., Terrand, J., Xu, B., Morrissy, S., Dinh, T. N., Williams, S., & Chen, Q. (2011). p21(WAF1/Cip1/Sdi1) knockout mice respond to doxorubicin with reduced cardiotoxicity. Toxicology and applied pharmacology, 257(1).
  18. Chen, Y., Xu, B., Strom, J., & Chen, Q. (2011). Dexamethasone induces transcriptional activation of Bcl-xL gene and inhibits cardiac injury by myocardial ischemia. European journal of pharmacology, 668(1-2).
  19. Chen, Y., Morrissy, S., Xu, B., Aguilar, D., Zhang, J., & Chen, Q. (2010). Inhibition of apoptosis by progesterone in cardiomyocytes. Aging cell, 9(5).
  20. Chen, Y., Xie, L., Terrand, J., Xu, B., Tsaprailis, G., Boyer, J., & Chen, Q. (2010). Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation. Cardiovascular research, 87(4).
  21. Chen, Y., Xie, L., Pandey, R., Xu, B., Tsaprailis, G., & Chen, Q. (2009). Genomic and proteomic profiling of oxidative stress response in human diploid fibroblasts. Biogerontology, 10(2).
  22. Chen, Y., Sun, H., & Chen, Q. (2008). Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes. Cardiovascular toxicology, 8(2).
  23. Chen, Y., Sun, H., Sheveleva, E., & Chen, Q. (2008). Corticosteroids induce cyclooxygenase 1 expression in cardiomyocytes: role of glucocorticoid receptor and Sp3 transcription factor. Molecular endocrinology (Baltimore, Md.), 22(9).
  24. Chen, Y., Sun, H., Sheveleva, E., Xu, B., Inoue, H., Bowden, T. G., & Chen, Q. (2008). Corticosteroids induce COX-2 expression in cardiomyocytes: role of glucocorticoid receptor and C/EBP-beta. American journal of physiology. Cell physiology, 295(4).
  25. Chen, Y., Sun, H., Xu, B., Inoue, H., & Chen, Q. (2008). P38 MAPK mediates COX-2 gene expression by corticosterone in cardiomyocytes. Cellular signalling, 20(11).
  26. Chen, Y., Sun, H., Xu, B., Sheveleva, E., & Chen, Q. (2008). LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism. Toxicology and applied pharmacology, 232(1).
  27. Pysher, M. D., Chen, Q. M., & Vaillancourt, R. R. (2008). Arsenic alters vascular smooth muscle cell focal adhesion complexes leading to activation of FAK-src mediated pathways. Toxicology and applied pharmacology, 231(2), 135-41.
  28. Chen, Y., Purdom-Dickinson, S. E., Lin, Y., Dedek, M., Morrissy, S., Johnson, J., & Chen, Q. (2007). Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor. Journal of molecular and cellular cardiology, 42(1).
  29. Chen, Y., Purdom-Dickinson, S. E., Sheveleva, E. V., Sun, H., & Chen, Q. (2007). Translational control of nrf2 protein in activation of antioxidant response by oxidants. Molecular pharmacology, 72(4).
  30. Chen, Y., Tu, V. C., Sun, H., Bowden, G. T., & Chen, Q. (2007). Involvement of oxidants and AP-1 in angiotensin II-activated NFAT3 transcription factor. American journal of physiology. Cell physiology, 292(4).
  31. Chen, Y., Purdom, S., & Chen, Q. (2005). Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts. The Journal of pharmacology and experimental therapeutics, 312(3).
  32. Chen, Y., Xie, L., Tsaprailis, G., & Chen, Q. (2005). Proteomic identification of insulin-like growth factor-binding protein-6 induced by sublethal H2O2 stress from human diploid fibroblasts. Molecular & cellular proteomics : MCP, 4(9).
  33. Chen, Y., Coronella-Wood, J., Terrand, J., Sun, H., & Chen, Q. (2004). c-Fos phosphorylation induced by H2O2 prevents proteasomal degradation of c-Fos in cardiomyocytes. The Journal of biological chemistry, 279(32).
  34. Chen, Y., Dilley, T. K., Bowden, G. T., & Chen, Q. (2003). Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity. Experimental cell research, 290(1).
  35. Chen, Y., Purdom, S., & Chen, Q. (2003). Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors. Biogerontology, 4(4).
  36. Chen, Y., Purdom, S., & Chen, Q. (2003). p66(Shc): at the crossroad of oxidative stress and the genetics of aging. Trends in molecular medicine, 9(5).
  37. Chen, Y., Tu, V. C., Bahl, J. J., & Chen, Q. (2003). Distinct roles of p42/p44(ERK) and p38 MAPK in oxidant-induced AP-1 activation and cardiomyocyte hypertrophy. Cardiovascular toxicology, 3(2).
  38. Chen, Y., Tu, V. C., Bahl, J. J., & Chen, Q. (2002). Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. The Journal of pharmacology and experimental therapeutics, 300(3).
  39. Chen, Q., & Chen, Q. (2000). Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints. Annals of the New York Academy of Sciences, 908.

Academic Information

Doctorate: 
Biochemistry, Clarkson University, Potsdam, NY