Assistant Professor, Psychiatry
Assistant Professor, Psychology
Dr. Pace is a biological psychologist with a primary interest in translational mind-body science in the context of stress, illness, and wellness. A major focus of his work today is the biology of wellness in cancer survivors, particularly women who have experienced breast cancer. He is especially interested in the development of novel intervention programs that target mind-body biological pathways, including endocrine and inflammatory immune systems.
Dr. Pace has 11+ years of experience measuring markers of the stress response, including key inflammatory biomarkers (e.g. interleukin-6 and nuclear factor-κB), and 7 years of experience with effectiveness research for different meditation programs. Besides the development of compassion meditation for breast cancer survivors, he is also keenly interested in the potential of natural products to reverse inflammation-associated fatigue experienced by breast cancer survivors.
Dr. Pace's research is supported by several NIH grants, including an R21 from NCI to explore the effectiveness of curcumin to attenuate inflammation and fatigue in survivors of breast cancer
Endocrine and immune system changes in stress-related psychiatric illness
Endocrine and inflammatory immune alterations as a result of adverse early life trauma
Novel contemplative interventions to optimize psychological, inflammatory immune, and endocrine responses to stress
Novel, natural anti-inflammatory compounds such as curcumin to promote health and wellness
- Torres MA, Pace TW, Liu T, Felger JC, Mister D, Doho GH, Kohn JN, Barsevick AM, Long Q, Miller AH. Predictors of depression in breast cancer patients treated with radiation: role of prior chemotherapy and nuclear factor kappa B. Cancer. 2013 Jun 1;119(11):1951-9. PubMed PMID: 23512358; PubMed Central PMCID: PMC3663885.
- Smith AK, Conneely KN, Pace TW, Mister D, Felger JC, Kilaru V, Akel MJ, Vertino PM, Miller AH, Torres MA. Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy. Brain Behav Immun. 2014 May;38:227-36. PubMed PMID: 24583204; PubMed Central PMCID: PMC4312666.
- Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol. 2012 Feb;12(2):368-77. PubMed PMID: 22197802; PubMed Central PMCID: PMC3372981.
- Pace TW, Negi LT, Adame DD, Cole SP, Sivilli TI, Brown TD, Issa MJ, Raison CL. Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology. 2009 Jan;34(1):87-98. PubMed PMID: 18835662; PubMed Central PMCID: PMC2695992.
- Pace TW, Negi LT, Sivilli TI, Issa MJ, Cole SP, Adame DD, Raison CL. Innate immune, neuroendocrine and behavioral responses to psychosocial stress do not predict subsequent compassion meditation practice time. Psychoneuroendocrinology. 2010 Feb;35(2):310-5. PubMed PMID: 19615827; PubMed Central PMCID: PMC3083925.
- Desbordes G, Negi LT, Pace TW, Wallace BA, Raison CL, Schwartz EL. Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state. Front Hum Neurosci. 2012;6:292. PubMed PMID: 23125828; PubMed Central PMCID: PMC3485650.
- Pace TW, Negi LT, Dodson-Lavelle B, Ozawa-de Silva B, Reddy SD, Cole SP, Danese A, Craighead LW, Raison CL. Engagement with Cognitively-Based Compassion Training is associated with reduced salivary C-reactive protein from before to after training in foster care program adolescents. Psychoneuroendocrinology. 2013 Feb;38(2):294-9. PubMed PMID: 22762896.
- Pace TW, Mletzko TC, Alagbe O, Musselman DL, Nemeroff CB, Miller AH, Heim CM. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry. 2006 Sep;163(9):1630-3. PubMed PMID: 16946190.
- Pace TW, Miller AH. Cytokines and glucocorticoid receptor signaling. Relevance to major depression. Ann N Y Acad Sci. 2009 Oct;1179:86-105. PubMed PMID: 19906234; PubMed Central PMCID: PMC3399249.
- Pace TW, Heim CM. A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities. Brain Behav Immun. 2011 Jan;25(1):6-13. PubMed PMID: 20934505.
- Pace TW, Wingenfeld K, Schmidt I, Meinlschmidt G, Hellhammer DH, Heim CM. Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder. Brain Behav Immun. 2012 Jan;26(1):13-7. PubMed PMID: 21801830.
2013-Present Assistant Professor, University of Arizona, Department of Psychiatry, Tucson, AZ
2013-Present Assistant Professor, University of Arizona, College of Nursing, Tucson, AZ
2007- 2013 Neuroscience Faculty, Emory University, Division of Biological and Biomedical Sciences, Atlanta, GA
2007- 2013 Member, Emory University, Emory Winship Cancer Institute, Atlanta, GA
2006- 2012 Assistant Professor, Emory University, Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA
2006- 2006 Adjunct Instructor, Spelman College, Department of Psychology, Atlanta, GA
2014 40 under 40 Honoree, Tucson Hispanic Chamber of Commerce and the Arizona Daily Star
2012 Fellow, Poptech Science
2008 Professional Development Award, President's Commission for LGBT Concerns, Emory University
2006 Travel Award, Psychoneuroimmunology Research Society
1998 Psychobiology Award, Albright College
2010-Present Member, American Psychological Association
2005-Present Member, Psychoneuroimmunology Research Society
2005-Present Member, American Association for the Advancement of Science