William Cance, MD

Deputy Director, UACC Phoenix
Email Address: 
Phone Number: 
(602) 827-2692

UACC Information

Street Address: 
626 N 6th St
Phoenix, AZ

Building: Arizona Cancer Center--Phoenix (#3005)
Room #: 2239

Research Information

Research Program: 
Therapeutic Development
Member Status: 
Research Member
Year of Membership Acceptance: 
2016
Selected Publications: 
  1. Cance WG, Vervaert C, Seigler HF. Transplantation of rat insulinoma allografts with cyclosporine A. Surgery 1983; 93:279-288. PMID: 6297107
  2. Bradley JA, Hamilton DNH, Brown MW, Cance WG, Jackson VS, Ledingham IM. Cellular defense in critically ill surgical patients. Crit Care Med 1984; 12:565-570. PMID: 6734223
  3. Cance WG, Wells SA Jr, Dilley WG, Welch MJ, Otsuka FL, Davie JM. Human parathyroid antigen: Characterization and localization with monoclonal antibodies. Proc Natl Acad Sci USA 1986; 83:6112-6116. PMID:3526352
  4. Cance WG, Wells SA Jr, Dilley WG, Welch MJ, Otsuka FL, Scott RW, Davie JM. Unique parathyroid cells membrane antigen(s): Radio localization with specific monoclonal antibodies. Surg Forum 1986; 37:410-412.
  5. Cance WG, Otsuka FL, Dilley WG, Scott RW, Davie JM, Welch MJ, Wells SA Jr. A potential new radiopharmaceutical for parathyroid imaging: Radiolabeled parathyroid-specific monoclonal antibodies. Part 1. Evaluation of (I-125)-labeled WG Cance 15 antibodies in a nude mouse model system. Nucl Med Biol Int J Radiat Appl Instrum 1988; 15(3):299-303. PMID: 3384679
  6. Otsuka FL, Cance WG, Dilley WG, Scott RW, Davie JM, Wells SA Jr, Welch MJ. A potential new radiopharmaceutical for parathyroid imaging: Radiolabeled parathyroid-specific monoclonal antibodies. Part 2. Comparison of (I-125)- and (In- 111)-labeled antibodies. Nucl Med Biol Int J Radiat Appl Instrum1988; 15(3):305-311. PMID: 3384678
  7. Cance WG, Brennan MF, Dudas ME, Huang C-M, Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med 1990; 323(21):1457-1562. PMID: 2233918
  8. Cance WG, Cohen AM, Enker WE, Sigurdson ER. The predictive value of a negative computed tomographic scan in 100 patients with rectal carcinoma. Dis Colon Rectum 1991; 34(9):748-751.PMID: 1914737
  9. Cance WG, Chaudhary N, Worman HJ, Blobel G, Cordon-Cardo C. Expression of the nuclear lamins in normal and neoplastic human tissues. J Exp Clin Cancer Res 1992; 11(4):233.
  10. Cance WG, Craven RJ, Liu ET. Expression polymerase chain reaction: a sensitive method for analysis of gene expression in human tumors. Surg Oncol 1992; 1(4):309-314. PMID:1341265
  11. Cance WG, Craven RJ, Weiner TM, Liu ET. Novel protein kinases expressed in human breast cancer. Int J Cancer 1993; 54(4):571-577. PMID: 8099900
  12. Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of focal adhesion kinase (FAK) gene and invasive cancer. Lancet 1993; 342(8878):1024-1025. PMID: 7796399
  13. Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of growth factor receptors the focal adhesion kinase (FAK) and other tyrosine kinases in human soft tissue tumors. Ann Surg Oncol 1994; 1(1):18-27. PMID: 7834423
  14. Weiner TM and Cance WG. Molecular mechanisms involved in tumorigenesis and their surgical implications. 1994; Am J Surg 167(4):428-434. PMID:8179089
  15. Owens LV, Weiner, T Xu L, Cance WG. Antisense to the focal adhesion kinase gene disrupts human sarcoma growth and adhesion. Surg Forum 1994; 45:501-503.
  16. Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welch PL, Simmons A, Naylor SL, Leach RJ, Lewis TB, Bowcock A, Liu ET. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15 and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 1994; 9(7):1977-1988. PMID: 8208544
  17. Joseph U, Seesko HG, Neumann K, Cance WG, Wells S, Rothmund M. Immunohistochemical studies on specificity and affinity of the BB5-antibody against human parathyroid tissue. Exp Clin Endocrinol 1994; 102(6):455-459. PMID: 7890022
  18. Cance WG, Craven RJ, Bergman M, Xu L, Alitalo K, Liu ET. Rak a novel nuclear tyrosine kinase expressed in epithelial cells. Cell Growth Differ 1994; 5:1347-1355. PMID: 7696183
  19. Craven R, Xu L, Weiner T, Fridell Y, Dent G, Srivastava S, Liu E, Cance WG. Receptor tyrosine kinases expressed in metastatic colon cancer. Int J Cancer 1995; 60(6):791-797. PMID: 7896447
  20. Owens LV, Huth JF, Cance WG. Insulinoma: Pitfalls in preoperative localization. Eur J Surg Oncol 1995; 21:326-328. PMID: 7781809
  21. Owens LV, Xu LH, Craven RJ, Dent GA, Weiner TM, Kornberg L, Liu ET, Cance WG. Overexpression of the focal adhesion kinase (FAK) in invasive and metastatic human tumors. Cancer Res 1995; 55(13):2752-2755. PMID: 7796399 WG Cance 16
  22. Eisenberg LB, Warshauer DM, Woosley JT, Cance WG, Bunzendahl H, Semelka RC. CT and MRI of hepatic focal nodular hyperplasia with peripheral steatosis. J Comp Asst Tomo 1995; 19(3):498-500. PMID: 7790565
  23. Owens LV, Cance WG, Huth JF. Retroperitoneal fibrosis treated with tamoxifen. Am Surg 1995; 61(9):842-844. PMID: 7661488
  24. Craven RJ, Cance WG, Liu ET. The nuclear tyrosine kinase RAK associates with the retinoblastoma protein pRb. Cancer Res 1995; 55(18):3969-3972. PMID: 7664264
  25. Karpeh MS, Brennan MF, Cance WG, Woodruff JM, Pollack D, Casper ES, Dudas ME, Latres E, Drobnjak M, Cordon-Cardo C. Altered patterns of retinoblastoma gene product expression in adult soft-tissue sarcomas. Br J Cancer 1995; 72(4):986-991. PMID:7547254
  26. Owens LV, Xu L-H, Dent GA, Yang X-H, Sturge GC, Craven RJ, Cance WG. Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann Surg Oncol 1996; 3(1):100-105. PMID: 8770310
  27. Schlund JF, Semelka RC, Kettritz U, Weeks SM, Kahlenberg M, Cance WG. Correlation of perfusion abnormalities on CTAP and immediate postintravenous gadoliniumenhanced gradient edho MRI. Abdom Imaging 1996; 21(1):49-52. PMID: 8672972
  28. Xu L-H, Owens LV, Sturge GC, Yang X, Liu ET, Craven RJ, Cance WG. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ 1996; 7(4):413-418. PMID: 9052982
  29. Semelka RC, Schlund JF, Molina PL, Bagley AS, Kahlenberg M, Mauro M, Weeks SM, Cance WG. Malignant liver lesions: comparison of spiral CT arterial portography and MR imaging for diagnostic accuracy cost and effect on patient care. J Magn Reson Imaging 1996; 6(1):39-43. PMID: 8851401
  30. Semelka RC, Worawattanakul S, Kelekis NL, John G, Cance WG, Woosley JT, Graham M, Lee JKT. Liver lesion detection characterization and effect on patient management; comparison of single-phase spiral CT and current MR techniques. J Magn Reson Imaging 1997; 7(6):1040-1047. PMID: 9400847
  31. Semelka RC, Worawattanakul S, Mauro MA, Bernard SA, Cance WG. Malignant hepatic tumors: Changes on MRI after hepatic arterial chemoembolization - preliminary findings. J Magn Reson Imaging 1998; 8(1:)48-56. PMID: 9500260
  32. Pisano EO, Braeuning MP, Cance WG. Advanced breast biopsy instrumentation: A critique. Acad Radiol 1998; 5:513-515. PMID: 9653469
  33. Clark J, Rosenman J, Cance WG, Halle J, Graham M. Extending the indications for breast-conserving treatment to patients with locally advanced breast cancer. Int J Rad Oncol Biol Phys 1998; 42:345-350. PMID: 9788414
  34. Xu L-H, Yang X, Craven RJ, Cance WG. The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells. Cell Growth Differ 1998; 9(12):999-1005. PMID: 9869300
  35. Li X, Dy RC, Cance WG, Graves LM, Earp HS. Interactions between two cytoskeletonassociated tyrosine kinases: Calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase. J Biol Chem 1999; 274(13):8917-8924. PMID: 10085136
  36. Semelka RC, Cance WG, Marcos HB, Mauro M. Liver metastases: comparison of current MR techniques and spiral CT during arterial portography for detection in 20 surgically staged cases. Radiology 1999; 213(1):86-91. PMID: 10540645
  37. Judson PL, He X, Cance WG, Van Le L. Over-expression of focal adhesion kinase a protein tyrosine kinase in ovarian carcinoma. Cancer 1999; 86(8):1551-1556. PMID: 10526262 WG Cance 17
  38. Cance WG, Stewart AK, Menck HR. The National Cancer Data Base report on treatment patterns for hepatocellular carcinomas. Improved survival of surgically resected patients 1985 – 1996. Cancer 2000; 88(4):912-920. PMID: 10679662
  39. Simmons RM, Cance WG, Iacocca MV. A giant juvenile fibroadenoma in a twelve year old girl: A case of breast conservation. Breast J 2000; 6(6):418-420. PMID: 11348404
  40. Cance WG, Harris J, Iacocca MV, Roche E, Yang X-H, Chang J, Simpkins S, Xu L-H. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 2000; 6(6):2417-2423. PMID: 10873094
  41. Xu L-H, Yang X, Bradham CA, Brenner DA, Baldwin AS, Craven RJ, Cance WG. The focal adhesion kinase suppresses transformation-associated anchorage-independent apoptosis in human breast cancer cells: Involvement of death receptor-related signaling pathways. J Biol Chem 2000; 275(39):30597-30604. PMID: 10899173
  42. Cance WG. Warren H. Cole M.D.: Visionary surgical-scientist and mentor. Surgery 2001; 130(5):891-892. PMID: 11685200
  43. Owens LV, Xu L-H, Marston WA, Yang X-H, Farber MA, Iacocca MV, Cance WG, Keagy BA. Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia. J Vasc Surg 2001; 34(2):344-349. PMID: 11496289
  44. Pisano ED, Kuzmiak C, Koomen M, Cance WG. What every surgical oncologist should know about digital mammography. Sem Surg Onc 2001; 20:181-186. PMID: 11523102
  45. Cance WG, Carey LA, Calvo BF, Sartor C, Sawyer L, Moore DT, Rosenman J, Ollila DW, Graham II M. Long-term outcome neoadjuvant therapy for locally advanced breast carcinoma: Effective clinical downstaging allows breast preservation and predicts outstanding local control and survival. Ann Surg 2002; 236(3):295-302. PMID: 12192316
  46. Golubovskaya V, Beviglia L, Xu L-H, Earp HS, Craven R, Cance WG. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem 2002; 277(41):38978-38987. PMID: 12167618
  47. Lark AL, Livasy C, Calvo B, Caskey L, Moore DT, Yang X-H, Cance WG. Overexpression of focal adhesion kinase (FAK) in primary colorectal carcinomas and colorectal liver metastases: Immunohistochemistry and real-time PCR analyses. Clin Cancer Res 2003; 9(1):215-222. PMID: 12538472
  48. Meyer T, Xu L-H, Chang J-L, Liu ET, Craven RJ, Cance WG. Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase. Intl J Cancer 2003; 104(2):139-146. PMID: 12569567
  49. Stitzenberg KB, Meyer AA, Stern SL, Cance WG, Calvo BF, Klauber-DeMore N, Kim HJ, Sansbury L, Ollila DW. Extracapsular extension of the sentinel lymph node metastasis: a predictor of nonsentinel node tumor burden. Ann Surg 2003; 237(5):607-612; discussion 612-613. PMID: 12724626
  50. Yang X, Hand RA, Livasy CA, Cance WG, Craven RJ. Overexpression of the receptor tyrosine kinase Tie-1 intracellular domain in breast cancer. Tumour Biol 2003; 24(2):61-69. PMID: 12853700
  51. Poole ME, Bernard SA, Churchel MA, Weissler MC, Calvo B, Cance WG, Ollila D, Koruda M, Behrns K, Detterbeck FC. A phase I study of gemcitabine and docetaxel for advanced stage solid tumors. Cancer Invest 2003; 21:350-354. PMID: 12901280
  52. Beviglia L, Golubovskaya V, Xu LH, Yang XH, Craven RJ, Cance WG. Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding detachment and apoptosis. Biochem J 2003; 373(pt):201-210. PMID: 12659633 WG Cance 18
  53. Golubovskaya VM, Gross S, Kaur AS, Wilson RJ, Xu LH, Yang XH, Cance WG. Simultaneous inhibition of focal adhesion kinase and Src enhances detachment and apoptosis in colon cancer cell lines. Mol Cancer Res 2003; 1(10):755-764. PMID: 12939401
  54. Lotz M, Wang H-F, Cance W, Matthews J, Pories S. Epidermal growth factor (EGF) stimulation can substitute for c-Src overexpression in promoting breast carcinoma invasion. J Surg Res 2003; 109:123-129. PMID: 12643853
  55. Lee JW, Kim YH, Park HB, Xu L-H, Cance WG, Block JA, Scully SP. The C-terminal domain of focal adhesion kinase reduces the tumor cell invasiveness in chondrosarcoma cell lines. J Orthop Res 2003; 21(6):1071-1080. PMID: 14554221
  56. Craven RJ, Lightfoot H, Cance WG. A decade of tyrosine kinases: from gene discovery to therapeutics. Surg Onc 2003; 12(1):39-49. PMID: 12689669
  57. Park HB, Golubovskaya V, Xu L, Yang X, Lee JW, Scully S, Craven RJ, Cance WG. Activated Src elevates adhesion survival and 2-integrin expression in human breast cancer cells. Biochem J 2004; 378(Pt. 2):559-567. PMID: 14629195
  58. Rhoads JM, Chen W, Gookin J, Wu GY, Fu Q, Blikslager AT, Rippe RA, Argenzio RA, Cance WG, Weaver EM, Romer LH. Arginine stimulates intestinal cell migration through a focal adhesion kinase-dependent mechanism. Gut 2004; 53(4):514-522. PMID: 15016745
  59. Kurenova E, Xu L, Yang X, Baldwin A, Craven R, Hanks S, Liu Z, Cance WG. Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor interacting protein. Mol Cell Biol 2004; 24(10):4361-4371. PMID: 15121855
  60. Golubovskaya V, Kaur A, Cance WG. Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites. Biochim Biophys Acta 2004; 25;1678(2-3):111-125. PMID: 15157737
  61. Mendenhall WM, Amos EH, Rout WR, Zlotecki RA, Hochwald SN, Cance WG. Adjuvant postoperative radiotherapy for colon cancer. Cancer 2004; 101(6):1338-1344. PMID: 15316945
  62. Lightfoot HM Jr, Lark A, Livasy CA, Moore DT, Cowan D, Dressler L, Craven RJ, Cance WG. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat 2004; 88(2):109-116. PMID: 15564794
  63. Livasy CA, Moore D, Cance WG, Lininger RA. Focal adhesion kinase overexpression in endometrial neoplasia. Appl Immunohistochem Mol Morphol 2004; 12(4):342-345. PMID: 15536334
  64. Lark AL, Livasy CA, Dressler L, Moore DT, Millikan RC, Geradts J, Iacocca M, Cowan D, Little D, Craven RJ, Cance WG. High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol 2005; 18:1289-1294. PMID: 15861214
  65. Golubovskaya VM, Finch R, Cance WG. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem 2005; 280(26):25008-25021. PMID: 15855171
  66. Smith CS, Golubovskaya VM, Peck E, Xu L-H, Monia BP, Yang, X, Cance WG. Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res 2005; 15(5):357-362. PMID: 16179862
  67. Golubovskaya VM and Cance WG. Focal adhesion kinase and cancer. Aust- As J Cancer 2005; 4: 4; 217-221.
  68. Ollila DW, Caudle AS, Cance WG, Kim HJ, Cusack JC, Swasey JE, Calvo BF. Successful minimally invasive parathyroidectomy for primary hyperparathyroidism without using WG Cance 19 intraoperative parathyroid hormone assays. Am J Surg 2006; 191(1):52-56. PMID: 16399106
  69. Garces CA, Kurenova EV, Golubovskaya VM, Cance WG. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res 2006; 66(3):1446-1454. PMID: 16452200
  70. Cuenca AG, Jiang H, Hochwald SN, Delano M, Cance WG, Grobmyer SR. Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer 2006; 107(3):459-466. PMID: 16795065
  71. Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG, Grobmyer SR. Presentation and management of gastrointestinal stromal tumors of the duodenum. Am Surg 2006; 72(8):719-722; discussion 722-723. PMID: 16913316
  72. Caudle AS, Tepper JE, Calvo BF, Meyers MO, Goyal LK, Cance WG, Kim HJ. Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomas. Ann Surg Oncol 2007; 14(2):577-582. PMID: 17119868
  73. Beierle EA, Trujillo A, Nagaram A, Finch R, Ma X, Vella J, Cance WG, Kurenova E, Golubovskaya V. N-Myc regulates focal adhesion kinase (FAK) expression. J Biol Chem 2007; 282(17):12503-12516. PMID: 17327229
  74. Beierle EA, Trujillo A, Nagaram A, Golubovskaya VM, Cance WG, Kurenova EV. TAE226 inhibits human neuroblastoma cell survival. Cancer Invest 2008; 26(2):145-151. PMID: 18259944
  75. Funa NS, Reddy K, Bhandarkar S, Kurenova EV, Yang L, Cance WG, Welsh M, Arbiser JL. Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo. J Invest Dermatol 2008; 128:(3):710-716. PMID: 17914455
  76. Golubovskaya VM, Virnig C, Cance WG. TAE226-Induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Mol Carcinog 2008; 47(3):222-234. PMID: 17849451
  77. Golubovskaya V, Finch R, Virnig C, Kweh F, Massoll N, Campbell-Thompson M, Wallace MR, Cance WG. p53 regulates FAK expression in human tumor cells. Mol Carcinog 2008; 47(5):373-382. PMID:17999388
  78. Golubovskaya VM, Finch R, Zheng M, Kurenova EV, Cance WG. The 7 amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in interaction with FAK and is critical for p53 functioning. Biochem J 2008; 411(1):151-160. PMID: 18215142
  79. Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 2008; 29(6)1096-1107.PMID: 18263593
  80. Grobmyer SR, Mortellaro VE, Marshall J, Higgs GM, Hochwald SN, Mendenhall NP, Copeland EM, Cance WG. Is there a role for routine use of MRI in selection of patients for breast-conserving cancer therapy? J Am Coll Surg 2008; 206(5);1045-1050; discussion 1050-1052. PMID: 18471753
  81. Beierle EA, Massoll NA, Hartwich J, Kurenova EV, Golubovskaya VM, Cance WG, McGrady P, London WB.: Focal adhesion kinase expression in human neuroblastoma: Immunohistochemical and real-time PCR analyses. Clin Cancer Res 2008; 14(11):3299-3305. PMID: 18519756
  82. Magis AT, Bailey KM, Kurenova EV, Hernandez Prada, JA Cance WG, Ostrov DA. Crystallization of the Focal Adhesion Kinase Targeting (FAT) domain in a primitive orthorhombic space group. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008; 64(Pt 6):564-566. PMID: 18540077 WG Cance 20
  83. Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D, Cance WG. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem 2008; 51(23):7405-7416. PMID: 18989950
  84. Waterman AL, Grobmyer SR, Cance WG, Hochwald SN. Is endoscopic resection of gastric gastrointestinal stromal tumors safe? Am Surg 2008 74(12):1186-1189. PMID: 19097534
  85. Cance WG and Golubovskaya VM. Focal Adhesion Kinase (FAK) versus p53: apoptosis or survival? Sci Signal 2008; 1(20):pe22. PMID: 18493017
  86. Kurenov SN, Cance W, Noel B, Mozingo D. Game-based mass casualty burn training. Stud Health Technol Inform 2009; 142; 142-144. PMID: 19377134
  87. Grobmyer SR, Cance WG, Copeland EM, Vogel SB, Hochwald SN. Is there an indication for initial conservative management of pancreatic cystic lesions? J Surg Oncol 2009; 100(5)372-374. PMID: 19267387
  88. Oh MA, Choi S, Lee MJ, Choi MC, Lee SA, Ko W, Cance WG, Oh ES, Buday L, Kim SH, Lee JW. Specific tyrosine phosphorylation of Focal Adhesion Kinase mediated by Fertyrosine kinase in suspended hepatocytes. Biochim Biophys Acta 2009; 1793(5)781-791. PMID: 19339212
  89. Golubovskaya VM, Conway -Dorsey K, Edmiston SN, Tse C-K, Lark AA, Livasy CA, Moore D, Millikan RC, Cance WG. FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer 2009; 125(7):1735-1738. PMID: 19521985
  90. Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG. Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol Carcinog 2009; 48(11): 1005-1017. PMID: 19479903
  91. Hochwald SN, Nyberg C, Zheng M, Zheng D, Wood C, Massoll NA, Magis A, Ostrov D, Cance WG, Golubovskaya V. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 2009; 8(15):2435-2443. PMID: 19571674
  92. Kurenova EV, Hunt DL, He DH, Fu AD, Massoll NA, Golubovskaya VM, Garces AG, Cance WG. Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility, and survival in vitro and tumor formation in vivo. Cell Cycle 2009; 8(14): 2266-2280. PMID:19556880
  93. Kurenova EV, Hunt DL, He D, Magis AT, Ostrov DA, Cance WG. Small molecule chloropyramine hydrocholoride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem 2009; 52(15):4716-4724. PMID: 19610651
  94. Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance W, Hochwald SN. Targeting of the protein interaction site between FAK and IGF-1R. Biochem Biophys Res Commun 2009; 388(2)301-305. PMID: 19664602
  95. Golubovskaya VM, Zheng M, Zhang L, Li J-L, Cance WG. The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. BMC Cancer 2009; 12(9):280. PMID: 19671193
  96. Grobmyer SR, Hemming AW, Harris N, Behrns K, Logan H, Kim RD, Chang M, Cance WG, Hochwald SN. A pilot prospective randomized trial of postoperative epoetin alfa in patients undergoing major operation for upper gastrointestinal malignancy. Am J Clin Oncol 2009; 32(6):570-573. PMID: 19675446
  97. Beierle EA, Trujillo A, Kurenova EV, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Mol Carcinog 2010; 49(3):224-234. PMID: 19885861 WG Cance 21
  98. Zheng D, Golubovskaya V, Kurenova E, Wood C, Massoll NA, Ostrov D, Cance WG, Hochwald SN. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Mol Carcinog 2010; 49(2):200-209. PMID: 19885860
  99. Cance W. Society of Surgical Oncology Presidential Address: The war on cancer – shifting from disappointment to new hope. Ann Surg Onc 2010; 17(8):1971-1978. PMID: 20180028
  100. Beierle EA, Ma X, Stewart J, Nyberg C, Trujillo A, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle 2010; 9(5)1005-1015. PMID: 20160475
  101. Golubovskaya VM, Cance W. Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci 2010; 15: 901-912. PMID: 17725966
  102. Golubovskaya VM, Cance W. FAK and P53 protein interactions. Anticancer Agents Med Chem 2011; (7):617-619. PMID: 21355845
  103. Cance W. 2011 Society of Surgical Oncology Heritage Award: Honoring Kirby I. Bland, MD. Ann Surg Oncol 2012; 19:1:7-10. PMID: 21881924
  104. Golubovskaya V, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov DA, Gelman IH, Cance WG. A small molecular Focal Adhesion Kinase (FAK) inhibitor, targeting Y397 site: 1-(2-Hydroxyethyl)-3,5, 7-triaza-1-azoniatricylo [3.3.1.13,7] decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo. Carcinogenesis 2012; 33(5):1004-1013. PMID: 22402131
  105. Ho B, Olson G, Figel S, Gelman I, Cance W, Golubovskaya V. Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem 2012; 287 (22): 18656-18673 PMID: 22493428.
  106. Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoli N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle 2012; 11(17): 3250-3259. PMID: 22894899
  107. Shaw CM, Grobmyer SR, Ucar DA, Cance WG, Reith JD, Hochwald SN. Elevated expression of RS2 in the progression from neurofibroma to malignant peripheral nerve sheath tumor. Anticancer Res 2012: 32(2) 439-443. PMID: 2287730
  108. Golubovskaya V, Palma BNL, Zheng M, Ho B, Magis A, Ostrov D, Cance, WG. A smallmolecule inhibitor, 5’-O-Tritylthymidine, targets FAK and Mdm-2 interaction and blocks breast and colon tumorigenesis in vivo. Anticancer Agents Med Chem 2013; 13(4): 532-545. PMID: 22292771
  109. Golubovskaya V, Ho B, Zheng M, Magis A, Ostrov D, Cance W. Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, CSRC and IGF-1R, Pyk-2 in vitro kinase activities. Anticancer Agents Med Chem 2013; 13(4): 546 - 554. PMID: 22292772
  110. Heffler M, Golubovskaya V, Conroy J, Liu S, Wang D, Cance W, Dunn KB. FAK and has inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes. Anticancer Agents Med Chem 2013; 13(4): 584 – 594. PMID: 22934709
  111. Golubovskaya V, Huang G, Baotran H, Yemma M, Morrison C, Lee J, Eliceiri B, Cance WG. Pharmacological blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Mol Cancer Ther 2013; 12(2): 162 - 172. PMID: 23243059
  112. Nurkin S, Kakaria VR, Ruiz DE, Cance WG, Tiszenkel HI. The role of faecal diversion in low rectal cancer: a review of 1791 patients having rectal resection with anastomosis WG Cance 22 for cancer with and without a proximal stoma. Colorectal Dis 2013:15(6): 309-316 PMID: 23586660.
  113. Cance WG, Kurenova E, Marlowe T, Golubovskaya V. FAK as a cancer target: Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics. Sci Signal. 2013 Mar 26; 6(268): pe10.doi: 10.1126/scisignal.2004021. PMID: 23532331
  114. Heffler M, Golubovskaya VM, Bullard Dunn K, Cance W. Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. Cancer Biol Ther 2013; 14(8): 761- 772. PMID: 23792569
  115. Golubovskaya VM, Ho B, Zheng M, Magis A, Ostrov D, Morrison C, Cance WG. Disruption of focal adhesion and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer 2013; 13(1):342. PMID: 23841915
  116. Cance WG. Editorial: Translation cancer research for surgeons: Surg Oncol Clin N Am 2013; 22 (4), VX - XVI. PMID: 24012406 117. Golubovskaya VM, Sumbler B, Ho B, Yemma M, Cance WG. MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells. Anticancer Agents Med Chem. 2014;14(1)18-28 PMID: 23438844
  117. Golubovskaya VM, Sumbler B, Ho B, Yemma M, Cance WG. MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells. Anticancer Agents Med Chem. 2014;14(1)18-28 PMID: 23438844
  118. Golubovskaya VM, Cance WG. Targeting the p53 pathway. Surg Oncol Clin N Am 2013; 22(4): 747 – 764. (Review) PMID: 24012397
  119. Kurenova E, Liao J, He DH, Hunt D, Yemma M, Bshara W, Seshadri M, Cance WG. The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. Oncotarget 2013; 4 (10): 1632-1646. PMID: 24142503
  120. Stewart JE, Ma X, Megison M, Nabers H, Cance WG, Kurenova EV, Beirele EA. Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma. Mol Carcinog. 2013 July 19. [Epub ahead of print]. PMID: 23868727
  121. Golubovskaya VM, Ho B, Conroy J, Liu S, Wang D, Cance WG. Gene expression profiling identifies important genes affected by R2 compound disrupting FAK and P53 complex. Cancers. Cancers 2014; 6 (1): 166-178. PMID: 24452144
  122. Beierle E, Ma X, Stewart JE, Megison M, Cance WG, Kurenova EV. Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines. Mol Carcinog. 2014:53: 230-242. PMID: 23065847
  123. Gogate PN, E, Ethirajan M, Kurenova E, Magis A, Pandey R, Cance WG. Design, synthesis and biological evaluation of novel FAK scaffold inhibitors targeting the FAKVEGFR3 protein-protein interaction. Eur J Med Chem 2014; 80C: 154-166. PMID: 24780592.
  124. Dy G, Golubovskaya V, Ylagan L, Pokharel S, Bshara W, Brese E, Morrison C, Cance WG, Miller A. The prognostic significance of focal adhesion kinase (FAK) expression in stage I non-small cell lung cancer. J Thorac Oncol 2014:9:1278-1284. PMID: 25122425
  125. Kurenova E, Ucar D, Liao J, Yemma M, Gogate P, Bshara W, Sunar U, Seshadri M, Hochwald S, Cance WG. A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells. Cell Cycle 2014; 13 (16): 2542-2553. PMID:25486195
  126. Golubovskaya V, Curtin L, Groman A, Sexton S, Cance WG. In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1,2,4,5-benzenetetramine WG Cance 23 tetrahydrochloride. Arch Toxicol 2015; 89(7): 1095-101. [E-pub 2014 Jun 12].  PMID: 24915938.
  127. Gogate P, Kurenova E, Ethirajan M, Liao J, Yemma M, Sen A, Pandey R, Cance WG. Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer. Cancer Lett 2014;353(2); 281-289. [E-pub 2014 July 24]. PMID: 25067788
  128. Platz T, Kukar M, Elmarzouky R, Cance WG, Abdelhalim A. Low dose four-dimensional computerized tomography with volume rendering reconstruction for primary hyperparathyroidism: How do I do it? World J Radiol 2014 6(9):726-729. PMID: 25276315.
  129. Kukar M, Platz TA, Schaffner TJ, Elmarzouky R, Groman A, Kumar S, M, Abdelhalim A, Cance WG. The use of modified 4-Dimensional computed tomography in patients with primary hyperparathyroidism: An argument for the abandonment of routine sestamibi single-positron emission computer tomography (SPECT). Ann Surg Oncol 2014 :1: 139-145. PMID: 25074663.
  130. O’Brien S, Golubovskaya VM, Conroy J, Liu S, Wang D, Liu B, Cance, WG. FAK inhibition with small molecule inhibitor Y15 decreased viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Oncotarget 2014; 5(17): 7945-7959. PMID: 25277205.
  131. Golubovskaya VM, Ylagan L, Miller A, Hughes M, Wilson J, Wang D, Brese E, Bshara W, Edge S, Morrison C, Cance, WG. High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. BMC Cancer 2014; 14: 769. PMID: 25326692
  132. Golubovskaya V, O’Brien S, Ho B, Heffler M, Conroy J, Hu Q, Wang D, Liu S, Cance WG. Down-regulation of ALDH1A3, CD44, or MDR1 sensitizes resistant cancer cells to FAK auotphosphorylation inhibitor Y15. J Cancer Res Clin Oncol 2015; 141(9): 1613-1631. PMID: 25656374.
  133. Li Z, Lebedyeva IO, Golubovskaya VM, Cance WG, Alamry KA, Faidallah HM, Hall CD, Katritzky AR. Synthesis and bioactivity of a Goralatide analog with antileukemic activity. Bioorg Med Chem 2015; 23(15): 5056-5060. PMID: 26048023.
  134. Stewart JE, Ma X, Megison M, Nabers H, Cance WG, Kurenova EV, Beierle EA. Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma. Mol Carcinog 2015: 54(1): 9-23. PMID: 23868727.
  135. Wilton J, Kurenova E, Pitzonka L, Gaudy A, Curtin L, Sexton S, Cance WG, and Fetterly G. Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs. Eur J Drug Metab Pharmacokinet 2016; 41(1):555-67. PMID: 25377246
  136. Zhang H, Shao H, Golubovskaya V, Chen H, Cance WG, Adjei A, and Dy G. Efficacy of focal adhesion kinase (FAK) inhibition in non-small cell lung cancer with oncogenicallyactivated MAPK pathways. Br J Cancer. 2016 In press.
  137. Marlowe T, Lenzo F, Figel S, and Cance WG. Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-kinase Inhibitors. Sci Transl Med. In submission 5-2016.

Professional Information

Positions and Honors: 
2016 Hero Award, Make-A-Wish Foundation, Metro NY and Western NY
2012 Who’s Who in Healthcare – Buffalo’s Business First
2011 Golden Apple Award, Roswell Park Cancer Institute – For dedication to outstanding teaching of Surgical Oncology Fellows
2010 - 2015 Buffalo Spree Magazine Top Doctors WG Cance 4
2008 2013 America’s Top Doctors for Cancer
2007 - 2015 America’s Top Doctors® (Castle Connolly Medical Ltd.) (Elected by peers)
2002 Hector MacLean Distinguished Professor of Cancer Research University of North Carolina Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina
2001 - 2003 America’s Top Doctors® (Castle Connolly Medical Ltd.) (Elected by peers)
1998 - 2002 James F. Newsome M.D. Endowed Term Professor in Surgical Oncology University of North Carolina-Chapel Hill
1994 Jefferson-Pilot Fellowship University of North Carolina - Chapel Hill
1994 American College of Surgeons- George H.A. Clowes Jr., M.D., F.A.C.S. Memorial Research Career Development Award
1991 American Cancer Society Clinical Oncology Career Development Award
1990 Upjohn Young Investigator Award
1989 American Cancer Society Clinical Oncology Fellowship
1981 International College of Surgeons Scholarship
1978 Graduation Summa cum Laude with Distinction in Zoology
1975 Angier B. Duke Memorial Scholarship Duke University
Other Experience and Professional Memberships/Affiliations: 
Professional Societies
2010 Member, Medical Society of the County of Erie
2010 Member, Buffalo Surgical Society
2009 Member, Western New York Chapter, American College of Surgeons
2004 Member, Association of Program Directors in Surgery
2004 Member, American Society of Clinical Oncology
2003 Member, Society of Surgical Chairs
2003 Fellow, Southeastern Surgical Congress
2002 - 2010 Member, Southern Surgical Association
2000 Member, Society of Clinical Surgery
2000 Member, American Society for Cell Biology
2000 Fellow, American Surgical Association
1996 Member, Surgical Biology Club I
1995 Member, Society of University Surgeons
1995 Fellow, American College of Surgeons
1994 Member, American Association of Endocrine Surgeons
1994 Member, American Association for Cancer Research
1992 Fellow, Society of Surgical Oncology
1991 Member, Association for Academic Surgery
1990 Member, Nathan A. Womack Surgical Society
 
Editorial Boards
2011 - 2013 Editorial Board, Journal of Clinical Oncology
2010 - Present Editorial Board, Journal of Gastrointestinal Oncology
2009 - 2015 Editorial Board, Annals of Surgical Oncology, Translational Research and Biomarkers Section
2005 - 2006 Section Editor of Laboratory Research, Annals of Surgical Oncology
2003 Editorial Board, Journal of the American College of Surgeons
2003 Editorial Board, Breast Disease
2003 Editorial Board, American College of Surgeons Web Portal
2002 - 2005 Associate Section Editor of Laboratory Research, Annals of Surgical Oncology
2000 - 2003 Editorial Board, Surgical Oncology
1999 - 2007 Editorial Board, Surgery
1996 - 2006 Editorial Board, Annals of Surgical Oncology
 
External Advisory Board
External Scientific Advisory Committee SPORE in Soft Tissue Sarcoma, Memorial Sloan Kettering Cancer Center
Board Certifications & Licenses: 
American Board of Surgery – Diplomat Certificate Number 34472 1989
Recertification 1998
Recertification 2009

Academic Information

Post Doctoral: 
Surgical Oncology Memorial Sloan-Kettering Cancer Center
Medical School: 
Duke University
Undergraduate School: 
BS Zoology, Duke University