The scientific goal of the Cancer Prevention and Control (CPC) Program is to develop and implement highly interactive, multidisciplinary cancer prevention and control research, training, and outreach that will lead to progressive reductions in cancer incidence, morbidity, and mortality. The depth and breadth of the Program provides a unique opportunity to span the full spectrum of primary, secondary, and tertiary prevention.
The CPC fosters high impact multidisciplinary and translational science that serves the University of Arizona Cancer Center (UACC) catchment area of Southern Arizona. Scientific goals are accomplished with integration of faculty from across the campus of the University of Arizona (UA) and are operationalized through cancer-site specific team science.
The Specific Aims of the CPC are:
- To advance cancer prevention knowledge and inform on interventions through epidemiological science. The CPC will utilize epidemiological approaches to identify biological, environmental, and lifestyle factors, as well as gene-environment interactions associated with cancer risk, morbidity, and mortality.
- To evaluate novel chemoprevention compounds and biomarkers that will impact cancer prevention. The CPC will conduct laboratory, translational, and clinical research studies to identify potential targets for cancer prevention and to evaluate chemoprevention strategies, including pharmaceuticals, nutraceuticals, and vaccines.
- To test behavioral, psychosocial, and quality of life (QOL)-targeted interventions with high potential to reduce cancer risk and improve cancer outcomes. The CPC will conduct behavioral, psychosocial, and quality of life research to develop or test interventions to reduce cancer incidence, morbidity, and mortality, as well as improve treatment outcomes with an emphasis on cancer survivorship.
These aims represent key thematic areas of research that work in synergy to advance scientific knowledge and Program impact. Researchers operationalize their efforts through interdisciplinary teams largely organized by cancer type and include women’s cancers (breast, ovarian), colorectal cancer, prostate cancer, and skin cancer. Studies are designed to integrate cutting-edge research activities across the continuum of cancer prevention and control and to address special populations and cancer burdens in the catchment area.
Select Research Publications (540 since 2010)
Burgess JL, Kurzius-Spencer M, O'Rourke MK, Littau SR, Roberge J, Meza-Montenegro MM, Gutierrez-Millan LE, Harris RB. Environmental arsenic exposure and serum matrix metalloproteinase-9. Journal of exposure science & environmental epidemiology 2013;23(2):163-9. Click here to view abstract
Dennis LK, Lynch CF, Sandler DP, Alavanja MC. Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. Environ Health Perspect. 2010 Jun;118(6):812-7. doi: 10.1289/ehp.0901518. Click here to view abstract
Hibler EA, Hu C, Jurutka PW, Martinez ME, Jacobs ET. Polymorphic Variation in the GC and CASR Genes and Associations with Vitamin D Metabolite Concentration and Metachronous Colorectal Neoplasia. Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):368-75. PMCID: PMC3275650. Click here to view abstract
Hsu C-H, Long Q, Li Y, Jacobs ET. A Nonparametric Multiple Imputation Approach for Data with Missing Covariate Values with Application to Colorectal Adenoma Data, Journal of Biopharmaceutical Statistics, 2014;24(3):634-48. PMID:24697618. Click here to view abstract
Jacobs ET, Hibler EA, Lance P, Sardo CL, Jurutka PW. (2013) Association between circulating concentrations of 25(OH)D and colorectal adenoma: a pooled analysis. International journal of cancer Journal international du cancer;133(12):2980-8. PMCID: 3797158. Click here to view abstract
Kurzius-Spencer M, Burgess JL, Harris RB, Hartz V, Roberge J, Huang S, Hsu CH, O'Rourke MK. (2013) Contribution of diet to aggregate arsenic exposures-An analysis across populations. Journal of exposure science & environmental epidemiology. Click here to view abstract
Sardo CL, Hibler EA, Roe DL, Harris RB, Thomson CA, Cisneroz M, Thompson PA, Martinez ME, Jacobs ET. Sedentary behavior is associated with colorectal adenoma recurrence. Cancer Causes Control, 2014 Oct;25(10):1387-95. PMID: 25060482. Click here to view abstract
Thomson CA, McCullough ML, Wertheim BC, Chlebowski RT, Martinez ME, Stefanick ML, Rohan TE, Manson JE, Tindle HA, Ockene J, Vitolins MZ, Wactawski-Wende J, Sarto GE, Lane DS, Neuhouser ML. (2014) Nutrition and Physical Activity Cancer Prevention Guidelines, Cancer Risk, and Mortality in the Women's Health Initiative. Cancer prevention research;7(1):42-53. Click here to view abstract
Thomson CA, Van Horn L, Caan B, Aragaki A, Chlebowski R, Manson JE, Rohan T, Tinker LF, Kuller L, Hou L, Lane D, Johnson KC, Vitolins M, Prentice R. Cancer incidence and mortality during the intervention and post intervention periods of the Women’s Health Initiative Dietary Modification Trail. Cancer Epidemiol Biomark Prev. doi: 10.1158/1055-9965.EPI-14-0922. Epub ahead of print September 25, 2014. PMCID: PMC4257879. Click here to view abstract
Wertheim, B.C., Martinez, M.E., Ashbeck, E.L., Roe, D.J., Jacobs, E.T., Alberts, D.S., and Thompson, P.A. (2009). Physical activity as a determinant of fecal bile acid levels. Cancer Epidemiol Biomarkers Prev 18, 1591-1598. Click here to view abstract
Chemoprevention and Biomarkers
Chow HH, Hakim IA. Pharmacokinetic and chemoprevention studies on tea in humans. Pharmacol Res. 2011 Aug;64(2):105-12. Epub 2011 May 20. Review. PMCID: PMC3152306. Click here to view abstract
Chow, H-H.S., Garland, L.L., Heckman-Stoddard, B.M., Hsu, C-H., Butler, V.D., Cordova, C.A., Chew, W., and Cornelison, T.L. A pilot clinical study of resveratrol in postmenopausal women with high body mass index: Effect on systemic sex steroid hormones. Journal of Translational Medicine 12:223, 2014. PMID: 25115686. Click here to view abstract
Curiel-Lewandrowski, C., Swetter, S.M., Einsphar, J.G., Hsu, C-H., Nagle, R., Sagerman, P., Tangrea, J.A., Parnes, H.L., Alberts, D.S., Chow, H-H.S. Randomized, double-blind, placebo controlled trial of sulindac in individuals at risk for melanoma: Evaluation of potential chemopreventive activity. Cancer 2012;118(23):5848-56. PMID: 22605570. Click here to view abstract
Dickinson SE, Rusche JJ, Bec SL, Horn DJ, Janda J, Rim SH, Smith CL, Bowden GT. The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog, 2014 Oct 12. Click here to view abstract
Jacobs ET, Martínez ME, Buckmeier JA, Lance P, May M, Jurutka PW. Circulating FGF-23 is associated with metachronous colorectal adenoma, J Carcinog, 2011 Feb 12;10:3. PMID:21383962. Click here to view abstract
Miller JA, Pappan K, Thompson PA, Want EJ, Siskos A, Keun HC, Wulff J, Hu C, Lang JE, Chow HH. Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention. Cancer Prev Res (Phila). 2014 Nov 11. pii: canprevres.0100.2014. [Epub ahead of print] PubMed PMID: 25388013. Click here to view abstract
Witte MH. Translational/personalized medicine, pharmaco/surgico/radiogenomics, lymphatic spread of cancer, and medical ignoromes.J Surg Oncol. 2011 May 1;103(6):501-7. PMID: 21480242 Click here to view abstract
Zhu M, Zhu Y, Lance P. TNFalpha-activated stromal COX-2 signalling promotes proliferative and invasive potential of colon cancer epithelial cells. Cell proliferation 2013;46(4):374-81. Click here to view abstract
Behavioral, Psychosocial and Quality of Life
Badger T, Segrin C, Pasvogel A, Lopez AM. The effect of psychosocial interventions delivered by telephone and videophone on quality of life in early-stage breast cancer survivors and their supportive partners. J Telemed Telecare 2013;19(5):260-5. Click here to view abstract
Badger TA, Segrin C, Hepworth JT, Pasvogel A, Weihs K, Lopez AM. Telephone-delivered health education and interpersonal counseling improve quality of life for Latinas with breast cancer and their supportive partners. Psycho-oncology 2013;22(5):1035-42. Click here to view abstract
Carvajal SC, Miesfeld N, Chang J, Reinschmidt KM, de Zapien JG, Fernandez ML, Rosales C, Staten LK. Evidence for long-term impact of Pasos Adelante: using a community-wide survey to evaluate chronic disease risk modification in prior program participants. Int J Environ Res Public Health. 2013 Oct 1;10(10):4701-17. doi: 10.3390/ijerph10104701. PMCID: PMC3823309. Click here to view abstract
Davis, R., Loescher, L.J., Rogers, J., Snyder, A., Harris, R. Project Students are Sun Safe (SASS): A university student-delivered skin cancer prevention program for children in grades 6-12. Journal of Cancer Education 2014; DOI 10.1007/s13187-014-0742-7. Click here to view abstract
Dennis LK, Lowe JB. Does artificial UV use prior to spring break protect students from sunburns during spring break? Photodermatol Photoimmunol Photomed. 2013;29(3):140-8. doi: 10.1111/phpp.12040. PubMed PMID: 23651274. Click here to view abstract
Garcia RZ, Carvajal SC, Wilkinson AV, Thompson PA, Nodora JN, Komenaka IK, Brewster A, Cruz GI, Wertheim BC, Bondy ML, Martínez ME. Factors that influence mammography use and breast cancer detection among Mexican-American and African-American women. Cancer Causes Control. 2012 Jan;23(1):165-73. Epub 2011 Nov 13. PMID: 22080276. Click here to view abstract
Gordon JS, Mahabee-Gittens EM, Andrews JA, Christiansen SM, Byron DJ. A randomized clinical trial of a web-based tobacco cessation education program. Pediatrics 2013;131(2):e455-62. PMCID: 3557402. Click here to view abstract
Hingle M, Ellison E, McKenzie N, Harris RB, Logan RA, Thomson CA. Effects of an SMS-based skin cancer prevention campaign in adolescents. Amer J Prev Med.47(5): 617-623, 2014. PMCID: PMC4250167. Click here to view abstract
Hongu N, Orr BJ, Roe DJ, Reed RG, Going SB. Global positioning system watches for estimating energy expenditure. J Strength Cond Res 2013;27(11):3216-20. Click here to view abstract
Loescher LJ, Hansen C, Hepworth JT, Quale L, Sligh J. A preliminary study of a video intervention to inform solid organ transplant recipients about skin cancer. Transplant Proc 2013;45(9):3187-9. PMCID: 3818294. Click here to view abstract