TOPIC: “Functional Contribution of Microbiome to Mouse Colon Cancer”
SPEAKER: Thomas Doetschman, PhD
WHERE: UAHS COM-T 6120
WHEN: Tuesday, Dec. 4, 2018 | 11:30 a.m. - 12:30 p.m.
About the Speaker
With good fortune to be involved in the development of the mouse genetic engineering field, Dr. Tom Doetschman has used that technology over the past 25 years to discover in vivo functions of the three TGFβ ligands and the high and low molecular weight isoforms of FGF2. The resulting mouse strains have led to a wide-ranging set of investigations from heart, bone and palate development to adult heart disease, autoimmune disease and colon cancer.
Dr. Doetschman's current research program focuses on modeling a human TGFβ3 SNP that leads to connective tissue disorders; and on TGFβ1 and SMAD3 function in T-cell homeostasis and colon cancer. He has established and directed genetically engineered mouse core facilities at the University of Cincinnati and the University of Arizona, was consultant for the establishment of mouse genetic engineering at the Institute of Molecular and Cell Biology in Singapore, and was the scientific advisor for development of the NCI-Frederick’s Mouse Models of Human Cancer Repository.
Dr. Doetschman has been Co-Director of the Experimental Mouse Shared Resource since 2008.