Elsa M Reyes-Reyes, PhD

Research Assistant Professor, Medicine

Phone Number: 
(520) 626-2871

Research Information

Research Program: 
Cancer Biology
Selected Publications: 


  1. Reyes EM, Camacho-Arroyo I, Nava G, Cerbón MA. “Differential Methylation in Steroid 5 alpha-reductase Isozyme Genes in Epididymis, Testis, and Liver of the Adult Rat.”  J Andrology.(1997)18:372-377.  PMID: 9283949
  2. Reyes-Reyes EM, Rosales C, Hernandez R, López I. “Regulating Mechanisms of Actin Cytoskeleton.” Boletín de Educación Bioquímica.(2000) 22:51-56.
  3. Reyes-Reyes EM, Mora N, Zentella A,  Rosales C. “Phosphatidylinositol 3-Kinase Mediates Integrin-dependent NF-kB and MAPK Activation Through Separate Signaling Pathways” J Cell Sci.(2001)114:1579-89.PMID:11282033
  4. Reyes-Reyes EM, Gonzalez G,Mora N, Rosales C. “β1 and β2 Integrins Activate Different Signaling Pathways in Monocytes.” Biochem J.. (2002)363:273-80. PMID:11931654
  5. Reyes-Reyes EM, George MD, Roberts JD, and Akiyama SK.“P- Selectin Activates Integrin-mediated Colon Carcinoma Cell Adhesion to Fibronectin.”Exp Cell Res(2006).312:4056-4069.PMID:17056038
  6. Reyes-Reyes EMand Akiyama S K. “Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells.” Exp Cell Res. (2008) 314:2212-23. PMID:18504038
  7. Franco R, Sanchez-Olea R, Reyes-Reyes EM, and Panayiotidis MI. “Enviromental Toxicity, Oxidative stress and Apoptosis: Ménage a Trios.” Mutat Res. (2009) 674:3-22. PMID:19114126.
  8. Reyes-Reyes EM, Teng Y, and Bates PJ. “AS1411 is Uptaken by Macropinocytosis and induces Macropinocytosis Hyperstimulation in Cancer Cells.” Cancer Res. (2010) 70:8617-29.PMID:20861190
  9. Reyes-Reyes EM, Teng Y, and Bates PJ. “AS1411 is Uptaken by Macropinocytosis and induces Macropinocytosis Hyperstimulation in Cancer Cells.” Cancer Res. (2010) 70:8617-29.PMID:20861190
  10. Farin K, Schokoroy S, Haklai R, Cohen-Or I, Elad-Sfadia G, Reyes-Reyes EM, Bates PJ, Cox AD, Kloog Y, Pinkas-Kramarski R. “Oncogenic Synergism between ErbB1, Nucleolin, and Mutant Ras.” Cancer Res. (2011)71:2140-5. PMID:21257709
  11. Reyes-Reyes EM, Jin Z, Vaisberg A, Hammod G, Bates PJ. “Physangulidine A, a new Withanolide from Physalis angulata, Perturbs Cell Cycle and Induces Cell Death by Apoptosis in Prostate Cancer Cells.” Journal of Natural Products. (2013) 76:2-7.PMID:23270478
  12. Salipur FR, Reyes-Reyes EM, Xu B, Hammond GB, and Bates PJ. “A Novel Small Molecule that induces oxidative stress and Selectively Kills Malignant Cells.” Free Radical Biology & Medicine.  (2014) 68:110-21. PMID: 24321317
  13. Anandhan A, Rodriguez-Rocha H, Bohovych I, Griggs A, Zavala-Flores L, Reyes-Reyes EM, Seravalli J, Stanciu L, Lee J, Rochet JC, Oleh Khalimonchuk O, Franco R. “Non-toxic alpha-synuclein overexpression increases dopaminergic cell death induced by environmental copper exposure via modulation of protein degradation pathways.” Neurobiol Dis. (2014) Dec 8. pii: S0969-9961(14)00364-7. PMID:25497688
  14. Reyes-Reyes EM, Šalipur FR, ShamsM, ForsthoefelM, Bates PJ. “Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.”  Mol Oncol. (2015)  9(7):1392-405. PMID:25911416
  15. Malik T, O'Toole, Casson L, Reyes-Reyes EM, Kang NG, Bates PJ. “AS1411-conjugated gold nanoparticles and their potential for breast cancer therapy.” Oncotarget. (2015) 6(26):22270-8. PMID:26045302
  16. Ramos, K.S., Reyes-Reyes, EM., Nanez. A. Overview of receptor systems. Reference Module in Biomedical Sciences (2015).
  17. Ramos, K.S., Reyes-Reyes, EM., Weber, T.J. Overview of alterations in cell signaling. Reference Module in Biomedical Sciences (2015).
  18. Reyes-Reyes EM, Ramos I, Tavera-Garcia MA, Ramos KS. The Aryl Hydrocarbon Receptor Agonist Benzo(a)pyrene Reactivates LINE-1 in HepG2 Cells Through Canonical TGF-b1 Signaling: Implications in Hepatocellular Carcinogenesis. Am J Cancer Res (2016) 6(5):1066-77 PMID: 27293999
  19. Bates PJ, Reyes-Reyes EM, Malik MT, Murphy EM, O'Toole MG, Trent JO. G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms. Biochim Biophys Acta. 2016 Dec 20. pii: S0304-4165(16)30509-8. doi: 10.1016/j.bbagen.2016.12.015. [Epub ahead of print] PMID:28007579
  20. Bojang P, Reyes-Reyes EM, Montoya-Durango DA, Ramos KS. LINE-1 Reactivation in Human Bronchial Epithelial Cells Requires Disassembly of NuRD Multiprotein Complex and Loss of Mi2β and MBD2/3 Corepressor Functions. Submitted Nucleic Acid Research (NAR-00227-2016)