Assistant Professor, Cellular and Molecular Medicine
Director, UACC Bioinformatics Shared Resource
I develop computational methods to integrate multi-'omics data and characterize how cellular networks are altered, both in structure and in function, by cancer. I have a special interest in tumor viruses, especially Merkel cell polyomavirus, and how they remodel the host cell network to induce cellular transformation. Through a combination of single-cell microscopy, RNA-sequencing, and network analysis, we have identified new pathways and gene modules that drive cancer phenotypes.
Another line of research is modeling drug response in cancer cell lines and tumors. I am developing a network-based algorithm to predict drug response based on the mutation profile and presence of tissue-specific factors in tumor cells.