Michael T Marty, PhD

Assistant Professor
Phone Number: 
(520) 621-1501
Professional Bio: 

Dr. Marty is an assistant professor of chemistry and biochemistry. He completed his Ph.D. in chemistry as a Springborn Fellow at the University of Illinois, Urbana-Champaign, in 2013, followed by postdoctoral research at the University of Oxford. He joined the UA faculty in 2016. His research applies lipoprotein nanodiscs with mass spectrometry to study membrane proteins and their interactions with lipid bilayers important in the study of fluid and chemicals movements through cells.

Research Information

Research Program: 
Therapeutic Development
Research Focus: 

Membrane proteins play a number of critical biochemical roles and make up the majority of drug targets. Despite their importance, membrane proteins remain challenging systems for analysis due to their amphipathic nature and low expression levels. Moreover, the lipid bilayer can play an important but largely unexplored role in regulating membrane protein structure and function. New analytical and biochemical methods are necessary to better understand and design drugs to target membrane proteins.

Selected Publications: 
  1. Marty, M.T.; Hoi, K.K.; Gault, J.; Robinson, C.V. “Probing the Lipid Annular Belt by Gas-phase Dissociation of Membrane Proteins in Nanodiscs” Angew. Chemie. Int. Ed. 2016, 55, 550-554.
  2. Marty, M.T.; Baldwin A.J.; Marklund, E.G.; Hochberg, G.K.A.; Benesch, J.L.P.; Robinson C.V. “Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles” Anal. Chem. 2015, 87, 4370-4376.
  3. Marty, M.T.; Zhang, H.; Cui, W.; Gross, M.L.; Sligar, S.G. “Interpretation and Deconvolution of Nanodisc Native Mass Spectra” J. Am. Soc. Mass Spectrom. 2014, 25, 269-277.
  4. Marty, M.T.; Wilcox, K.C.; Klein, W.L.; Sligar, S.G. “Nanodisc-Solubilized Membrane Protein Library Reflects the Membrane Proteome” Anal. Bioanal. Chem. 2013, 405, 4009-4016.
  5. Marty, M.T.; Zhang, H.; Cui, W.; Blankenship, R.E.; Gross, M.L.; Sligar, S.G. “Native Mass Spectrometry Characterization of Intact Nanodisc Lipoprotein Complexes” Anal Chem. 2012, 84, 8957-8960.

Academic Information

Post Doctoral: 
University of Oxford
University of Illinois at Urbana-Champaign
Undergraduate School: 
BA, St. Olaf College