Professor, Cancer Biology - GIDP
Director of Gynecologic Oncology
Director of Women's Cancers
As a nationally recognized physician-scientist elected to the IOM, Dr. Chambers has expertise spanning very basic thorough translational research, clinical trials including investigator-initiated clinical trials, to active clinical care. She has directed a laboratory devoted to understanding the molecular basis for breast and ovarian cancer metastasis and initiation for over 2 decades. Her laboratory continues to study UTR regulators of gene expression, including RNA binding proteins and miRNAs. Her breast cancer research focuses on the interactions within the tumor microenvironment (TME) which enable breast cancer cells to metastasize and thrive in bone, and to cause bone destruction.
In ovarian cancer, Dr. Chambers focuses on the parameters in the TME which regulate metastatic ovarian cancer implantation, growth, and invasion, as well as an increasing focus on TME influence on tumor initiation in the fallopian tube. She is the team leader within the Clinical Protocol and Data Monitoring unit of the University of Arizona Cancer Center for gynecologic oncology trials, which includes cooperative group (NRG/GOG-partners primarily, with SWOG in the past), industry-sponsored and investigator-initiated trials. These trials include those which focus on early detection, biomarker identification, quality of life, as well as those with therapeutic intent. Collectively, she can best be described as a serious translational scientist.
Dr. Chambers has leadership roles in several contexts, in the department of Obstetrics and Gynecology as Vice Chair and Section Head of Gynecologic Oncology as well as in the Cancer Center, as Director of Women’s Cancers. After 5 years, she has recently stepped down as co-leader of the Cancer Biology Program, one of 4 major programs in our NCI Comprehensive Cancer Center. During that time, Dr. Chambers helped successfully compete for the CCSG renewal. She established in 2006 and served as PI of the Cancer Center tumor biorepository (wherein Gynecology Oncology is responsible for 39% of total accruals), and developed the High Risk Clinic for women at risk for breast and ovarian cancer in 2004.
As a translational scientist, Dr. Chambers also has reviewed or continues to review grants for a number of national entities, including the NIH, DOD, and others. In particular, she has been asked to serve on multiple NIH SPORE review panels starting in 2008. She has recently become co-founding Editor-in-Chief for a new open access journal: American Journal of Clinical and Experimental Obstetrics and Gynecology.
As an educator, Dr. Chambers also has extensive experience mentoring gynecologic oncology fellows, residents, students, and post-doctoral fellows. During her tenure at Yale, she helped direct and mentor 15 fellows in her role as Director of gynecologic oncology fellowship research, then Director of the Gynecologic Oncology Fellowship Program. In 2004, Dr. Chambers joined the faculty at the University of Arizona where she continues to actively mentor faculty, residents, post-docs, and undergraduate students in her laboratory, in the clinical setting, and through her leadership positions.
Dr. Chambers served as an advisory external site visitor for the NICHD sponsored WRHR career development program, as well as on several review committees for mentored grants.
Dr. Chambers received her BS and MD degrees from Brown University. She completed her residency in Obstetrics and Gynecology as well as a fellowship in Gynecologic Oncology at Yale University. She remained at Yale as a member of the faculty until 2004. During her tenure at Yale, she was Director of the Gynecologic Oncology fellowship program and, until recently, was the only woman professor in Obstetrics and Gynecology. Throughout her career, Dr. Chambers has served on many national and regional committees, grant review panels and study sections. She is an examiner for the American Board of Obstetricians and Gynecologists and has served as President of the New England Association of Gynecologic Oncologists. She has authored over 80 peer reviewed publications and chapters.
Dr. Chambers is one of the few gynecologic oncologist physician-scientists in the country, active as both a researcher and clinical gynecologic oncologist, evaluating oncology patients at The University of Arizona Cancer Center. Her research laboratory, which is funded by both the National Cancer Institute and Department of Defense, is devoted to understanding the molecular basis for breast and ovarian cancer invasion and metastasis.
Dr. Chambers moved to Tucson to become director of the newly created Division of Women's Cancers at The University of Arizona Cancer Center. Her current role is to develop a comprehensive Women's Cancers program, encompassing both research and clinical practice in the areas of breast and gynecologic cancers. Her multidisciplinary division is comprised of gynecologic oncologists, surgical oncologists, medical oncologists, radiation oncologists, and translational and basic science researchers. Collectively, these experts seek to deliver exemplary, cutting-edge care to women throughout the Southwest who either have cancer or are at risk for developing this disease.
- CSF-1 and its role in neoplastic progression of breast and ovarian cancer
- Androgens and neoplastic transformation of normal ovarian surface epithelium
- The c-fms proto-oncogene and breast cancer invasiveness
POSITIONS HELD IN REGIONAL AND NATIONAL SOCIETIES:
- Society of Gynecologic Oncologists, 1995 Scientific Program Committee.
- Society for Gynecologic Investigation, 1996 Task Force on strengthening basic research in academic departments.
- Society for Gynecologic Investigation, Program Committee, 1997-1998, 2001, 2002, Senior Reviewer 2001, 2005, 2008.
- New England Association of Gynecologic Oncologists, Secretary-Treasurer, 1996-1999.
- New England Association of Gynecologic Oncologists, President-Elect, 2000.
- Society for Gynecologic Investigation, Session Chair, Invited Lectures, March 2000.
- Society for Gynecologic Investigation, Nominating Committee, 2000.
- New England Association of Gynecologic Oncologists, President, 2001.
- Society for Gynecologic Investigation, Membership Committee, 2002-2005.
- Faculty, ACOG course “Controversies in Gynecology”, February 2002, Los Cabos, Mexico.
- Society for Gynecologic Investigation, Nominating Committee, 2003.
- Faculty, ACOG course “Controversies in Gynecology”, June 2003, Victoria, British Columbia.
- Society of Gynecologic Oncologists, 2002, 2003, Candidate and Fellow Career Development Forum; Mentoring on Grantsmanship
- American Society of Clinical Oncology, Scientific Program Committee, 2003-2005.
- Society for Gynecologic Investigation, 2004 Program Committee Subsection Member.
- American Gynecological and Obstetrical Society, member 2003.
- American Association of Obstetricians and Gynecologists Foundation (AAOGF) Endowment Fund Committee, member 2004-2007; second term 2007-2010.
- Faculty, ACOG course “Controversies in Gynecology”, December 2004, Chicago, IL.
- Faculty, Society of Gynecologic Oncologists, Miami, FL, March 2005, post-graduate course “Molecular Biology for Dummies.”
- Faculty, ACOG course “Gynecologic Oncology for the Generalist”, May 2005, San Francisco, CA.
- Faculty, ACOG course “Gynecologic Oncology for the Generalist”, May 2006, Washington, DC.
- Course Director, 37th Annual Tucson Seminar, ‘Focus on Women’s Cancers’, January 2006, Tucson, AZ.
- Course Director, 37th Annual Tucson Seminar, ‘Focus on Women’s Cancers, Nursing Conference’, January 2006, Tucson, AZ.
- Course Director, ACOG course “Gynecologic Oncology for the Generalist”, 2007-2009 (gave this up).
- American Gynecological and Obstetrical Society, Council, 2007-2010.
- Society of Gynecologic Oncologists, abstract reviewer, 2007.
- Southwest Oncology Group, Gynecology Committee member, 2007-present. • Gynecologic Oncology Group, affiliate site Principal Investigator, 2008-present.
SCIENTIFIC SOCIETIES (YEAR OF MEMBERSHIP):
- American Society of Clinical Oncology (1987)
- American Association for Cancer Research (1988)
- American College of Obstetrics & Gynecology (Junior Fellow 1981 Fellow 1989)
- American Medical Women's Association (1990)
- New England Association of Gynecologic Oncologists (1989)
- Society of Gynecologic Oncologists (1990)
- International Gynecologic Cancer Society (1991)
- Society for Gynecologic Investigation (1993)
- American Gynecological and Obstetrical Society (AGOS, 2003)
- Gynecologic Oncology Group (2003), Southwest Oncology Group (SWOG, 2007)
- Diplomate of the National Board of Medical Examiners, 1981
- Board Certified, American Board of Obstetrics & Gynecology, Obstetrics and Gynecology, 1987
- Board Certified, American Board of Obstetrics & Gynecology, Division of Gynecologic Oncology, 1988
- Recertification, American Board of Obstetrics & Gynecology, Obstetrics and Gynecology and Gynecologic Oncology, 1997, 2007, 2008, 2009