Wolfgang Peti, PhD

Professor, Chemistry and Biochemistry
Phone Number: 
(520) 621-3489

Research Information

Research Program: 
Therapeutic Development
Research Focus: 
Protein function originates from a cooperation of structural rigidity, dynamics at different timescales and allostery. However, how these three pillars of protein function are integrated is still only poorly understood. We are using different molecular techniques to understand how function and activity is created by phosphorylation enzymes, especially kinases and phosphatases.
Selected Publications: 
  1. Ragusa, M.J., Dancheck, B., Critton, D.A., Nairn, A.C., Page, R. & Peti, W. (2010) Spinophilin directs Protein Phosphatase 1 specificity by steric inhibition of substrate binding sites, Nat Struct Mol Biol,17(4), 459-464.
  2. Wang, W., Kim, Y., Ma, Q., Hong, S.H., Brown, B.L., Benedik, M.J., Peti, W., Page, R. & Wood, T.K. (2011) Antitoxin MqsA Helps Mediate the Bacterial General Stress Response, Nat Chem Biol, 7(6), 359-366.
  3. Wang, X., Lord, D.M., Cheng, H.-Y., Osbourn, D.O., Hong, S.H., Sanchez-Torres, V., Quiroga, C., Herrmann, T., Peti, W., Benedik, M.J., Page, R. & Wood, T.K. (2012) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS, Nat Chem Biol, 8, 855-861.
  4. Grigoriu, S., Bond, R., Cossio, P., Chen, J.A., Ly, N., Hummer, Page, R., Cyert, M.S. & Peti, W. (2013) The molecular mechanism of substrate engagement and immunosuppressant inhibition of Calcineurin. PLoS Biology, 11(2), e1001492
  5. Choy, M.S., Hieke, M., Kumar, G.S., Lewis, G.R. Gonzalez-DeWhitt, K.R., Kessler, R.P., Stein, B.J., Hessenberger, M., Nairn, A.C., Peti, W. & Page, R. (2014) Understanding Retinoblastoma Protein activation by PNUTS leads to the identification of the Protein Phosphatase 1 Regulatory Code, Proc Natl Acad Sci U S A, 111(11), 4097-4102.
  6. Krishnan, N., Koveal, D., Miller, D.H., Kragelj, K., Ringkjøbing Jensen, M., Gauss, K., Xue, B., Muthuswamy, S.K., Page, R., Blackledge, M., Peti, W. & Tonks, N.K. (2014) A novel mechanism of allosteric inhibition of protein tyrosine phosphatase PTP1B reveals a new strategy for therapeutic development, Nature Chemical Biology, 10(7), 558-566.
  7. Choy, M.S., Yusoff, P., Lee, I.C., Newton, J.C., Goh, C.W., Page, R., Shenolikar, S. & Peti, W. (2015) Structural and functional analysis of the GADD34:PP1 eIF2α phosphatase, Cell Reports, 11, 1885-1891
  8. Kumar, G.S., Ezgi, G., De Munter, S., Bollen, M., Vagnarelli, P., Peti, W. & Page, R. (2016) Molecular Assembly of the Ki-67:PP1 and RepoMan:PP1 Mitotic Phosphatases: Regulators of Chromatin Organization and Structure, Elife, 5:e16539.
  9. Wang, X., Bajaj, R., Bollen, M., Peti, W. & Page, R. (2016) Expanding the PP2A Interactome by Defining a B56-specific SLiM, Structure, 24(12):2174-2181.
  10. Sheftic, R.S., Page, R. & Peti, W. (2016) Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM, Nature Sci. Reports, 6:38920.

Professional Information

Positions and Honors: 

2017 – present Homer C. and Emily Davis Weed Chair
1/2015-12/2017 Permanent Member of the American Diabetes Association's Research Grant Review Committee
7/2016 – 6/2020 Permanent Member NIH/MIST (Molecular and Integrative Signal Transduction) study section
2/2017 – present Associate Editor (Structural Biology, Molecular Mechanism of Signal Transduction, Phosphates, NMR spectroscopy and X-ray crystallography): Journal of Biological Chemistry
2014 – present Pathway to Stop Diabetes American Diabetes Association Fellow
2013 – 2017 Editorial Member: Journal of Biological Chemistry
2007 – 2010 Manning Assistant Professor of Medical Science
2005 Rhode Island Foundation Medical Research Grant
2005 Richard B. Salomon Faculty Research Award
2004 Max-Kade Foundation Fellowship Award
2002 Ernst Award 2002 of the German Chemical Society
2001 European Union Research Training Network "Cross-Correlation" Young Investigator HPRN-CT-2000-00092
1998 – 2001 Member of the University Sponsor group of the Bayer AG
1998 – 2001 Kekulé thesis scholarship from the scholarship fund of the association of the chemical industry in Germany
1996 – 1998 Performance scholarship of the ministry for science and culture in Austria

Academic Information

Post Doctoral: 
The Scripps Research Institute
Chemistry, summa cum laude, J.-W.-G. University Frankfurt, Germany
Master's Degree: 
MS, Diploma Magister rer. nat, Chemistry, summa cum laude, University of Vienna, Austria
Undergraduate School: 
BS, Diploma Magister rer. nat, Chemistry, summa cum laude, University of Vienna, Austria