List of recent publications (2009-2015) by past and present UACC members who have made use of the PSR.

We gratefully acknowledge support by the National Cancer Institute that made all this work possible.

If your publication does not appear here, please notify Dr. George Tsaprailis.


Kimzey MJ, Kinsky OR, Yasine HN, Tsaprailis G, Stump CS, Monks TJ, Lau SS., Site Specific modification of the human plasma proteome by methylglyoxal., Toxicol. Appl. Pharmacol., doi: 10.1016/j.taap.2015.09.029. [Epub ahead of print]. 2015. PMID 2643512.

Csosz E, Emri G, Kallo G, Tsaprailis G, Tozser J.,  Highly abundant defense proteins in human sweat as revealed by targeted proteomics and label-free quantification mass spectrometry., J. Eur. Acad. Dermatol. Venereol. , doi: 10.1111/jdv.13221. Epub 2015 Aug 25. 2015. PMID 26307449.

Mehus AA, Reed RJ, Lee VS, Littau SR, Hu C, Lutz EA, Burgess JL. Comparison of Acute Health Effects From Exposures to Diesel and Biodiesel Fuel Emissions. J. Occup. Environ. Med. 2015. 57(7):705-712. PMID 26147538. PMC 4479787.

Mitchell SF, Parker R. In vivo cross-linking followed by polyA enrichment to identify yeast mRNA binding
proteins. 2015. Methods Mol Biol. 1259:35-47. doi: 10.1007/978-1-4939-2214-7_3

Yuan CC, Ma W, Schemmel P, Cheng YS, Liu J, Tsaprailis G, Feldman S, Ayme Southgate A, Irving TC. Elastic proteins in the flight muscle of Manduca Sexta. Arch. Biochem. Biophys. 2015. 568C:16-27. PMID 25602701.

Berry RE, Yang F, Shokhireva TK, Amoia AM, Garrett SA, Goren AM, Korte SR, Zhang H, Weichsel A, Montfort WR, Walker FA. Dimerization of Nitrophorin 4 at Low pH and Comparison to the K1A Mutant of Nitrophorin 1. Biochemistry 2015. 54(2):208-220.  PMID: 25489673. PMC 4303305


Kang HJ, Kendrick S, Hecht SM, Hurley LH. The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J AM Chem Soc. 2014. 136:4172-85.  PMID 24559432. PMC 3985447

Sollome JJ, Thavathiru E, Camenisch TD, Vaillancourt RR. HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). Cell Signal 2014. 26:70-82. PMID 24036211. PMC3869707

Purohit R, Fritz BG, The J, Issaian A, Weichsel A, David CL, Campbell E, Hausrath AC, Rassouli-Taylor L, Garcin ED, Gage MJ, Montfort WR. YC-1 Binding to the β Subunit of Soluble Guanylyl Cyclase Overcomes Allosteric Inhibition by the α Subunit. Biochemistry 2014. 53:101-114. PMID 24328155. PMC3914721

Radhakrishnan VM, Kojs P, Young G, Ramalingam R, Jagadish B, Mash EA, Martinez JD, Ghishan FK, Kiela PR. pTyr421 Cortactin is Overexpressed in Colon Cancer and is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1). PLoS One 2014. 9(1):e85795. PMID 24465712. PMC3899080


Spooner E, McLaughlin BM, Lepow T, Durns TA, Randall J, Upchurch C, Miller K, Campbell EM, Fares H. Systematic screens for proteins that interact with the mucolipidosis type IV protein TRPML1. 2013. PLoS One. 2013;8(2):e56780. PMCID: 3572064. PMID: 23418601

Hidalgo CG, Chung CS, Saripalli C, Methawasin M, Hutchinson KR, Tsaprailis G. Labeit S, Mattiazzi A, and Granzier HL. The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIdelta) phosphorylates cardiac titin's spring elements. J. Mol. Cell Cardiol. 2013. 54:90-97. PMID 23220127. PMC3535572

Mitchell SF, Jain S, She M, and Parker R. Global analysis of yeast mRNPs. Nat. Struc. Mol. Biol. 2013. 20(1):127-133. PMID 23222640. PMC3537908

Wysocka-Kapcinska M, Torocsik B, Turiak L, Tsaprailis G, David CL, Hunt AM, Vekey K, Adam-Vizi V, Kucharczyk R and Chinopoulos C. The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast. PLoS One, 2013. 8(9): e74187. PMID 24073201. PMC3779231

Fritz BG, Roberts SA, Ahmed A, Breci L, Li W, Weichsel A, Brailey JL, Wysocki VW, Tama F and  Montfort WR. Molecular Model of a Soluble Guanylyl Cyclase Fragment Determined by Small-Angle X-ray Scattering and Chemical Cross-Linking. Biochemistry. 2013. 52(9):1568-1582. PMID 23363317. PMC3607398

Monks TJ and Lau SS. Reactive Intermediates: Molecular and MS-based approaches to assess the functional significance of chemical-protein adducts. Toxicol. Pathol. 2013. 41(2):315-321. PMID 23222993. PMC4007760

Yassine H, Borges CR, Schaab MR, Billheimer D, Stump C, Reaven P, Lau SS and Nelson R. Mass spectrometric immunoassay and MRM as targeted MS-based quantitative approaches in biomarker development: Potential applications to cardiovascular disease and diabetes. Proteomics Clic. Appl. 2013. 7:528–540. PMID
23696124. PMC4029342

Woo HH, Baker T, Laszlo C and Chambers SK. Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation, but increases translation of CSF-1 mRNA. Mol. Cell. Proteomics. 2013. 12:1661-1677. (Cover paper). PMID 23471483. PMC3675821.

Karn RC, Chung AG, Laukaitis CM. Shared and unique proteins in human, mouse and rat saliva proteomes: Footprints of functional adaptation. Proteomes. 2013 1:275-289. PMID: 24926433. PMCID: PMC4051352.


Zhang J, Thai ND, Kappeler K, Tsaprailis G, Chen QM. La Autoantigen Mediates Oxidant Induced De Novo Nrf2 Protein Translation. Mol. Cell. Proteomics. 2012, 11(6):M111.015032. PMID 22207702. PMC3433904

Chuang Y, Xu X, Kwiatkowska A, Tsaprailis G, Hwang H, Petritis K, Flynn D, Symons M. Regulation of synaptojanin 2 5'-phosphatase activity by Src. Cell Migration & Adhesion 2012, 6(6):518-525. PMID 23076136.  PMC3547897

Kinsky OR, Kimzey MJ, Allred SF, Yassine HN, Tsaprailis G, Stum C, Billheimer D, Monks TJ, Lau SS. Site-specific arginine dicarbonyl modifications of serum albumin are reduced in metformin-controlled T2DM patients. FASEB J. 2012, 26:1122.1.

Kuhlman CL, Petersen DR, Tsaprailis G, Monks TJ, Lau SS. 4-Hydroxy-2-nonenal-Modified Proteins in Bone Marrow of Phenol/Hydroquinone Treated Rats: Implications for Benzene-Mediated Hematotoxicity. FASEB J. 2012, 26:1050.12.

Wolk DM, Kaleta EJ, Wysocki VH. PCR-electrospray ionization mass spectrometry:the potential to change infectious disease diagnostics in clinical and public health laboratories. J Mol Diagn. 2012 14:295-304. PubMed PMID: 22584138.

Flores RJ, Li Y, Yu A, Shen J, Rao PH, Lau SS, Vannucci M, Lau CC, Man TK. A systems biology approach reveals common metastatic pathways in osteosarcoma. BMC Systems Biology. 2012; 6:50.  PMID: 22640921.


Kimzey MJ, Yassine HN, Riepel BM, Tsaprailis G, Monks TJ and Lau SS. New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism. Chem. Biol. Interact. 2011. 192(1-2): 122-128. PMID 20934417. PMC3050118

Crabbé A, Schurr MJ, Monsieurs P, Morici L, Schurr J, Wilson JW, Ott CM, Tsaprailis G, Pierson DL, Stefyshyn-Piper H and Nickerson CA. Transcriptional and proteomic responses of pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen. Appl. Environ. Microbiol. 2011. 77(4): 1221-1230. PMID 21169425. PMC3067220

Brown RV, Danford FL, Gokhale V and Hurley LH. Demonstration that drug-targeted down-regulation of MYC in Non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J. Biol. Chem. 2011. 286(47): 41018-21027. PMID 21956115. PMC3220475

Fisher AA, Labenski MT, Malladi S, Chapman JD, Bratton SB, Monks TJ and Lau SS. The Frequency of 1-4-benzoquinone-lysine adducts in cytochrome c correlates with defects in apoptosome activation. Toxicol. Sci. 2011. 122(1): 64-72. PMID 21527774. PMC3203403

Kimzey MJ, Zarate X, Galbraith DW and Lau SS. Optimizing microarray-based in situ transcription-translation of proteins for matrix-assisted laser desorption ionization mass spectrometry. Anal. Biochem. 2011. 414: 281-286. PMID 21477576.  PMC4120701

Wnek SM, Kuhlman CL, Cmarillo JM, Medeiros MK, Liu KJ, Lau SS and Gandolfi AJ. Interdependent genotoxic mechanisms of monoethylarsonous acid: Rol of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicol. Appl. Pharm. 2011. 257:1-13. PMID 21925530. PMC3220758

Lamore SD, Qiao S and Wondrak GT. Proteomic indentification of cathepsin B as a novel target of UVA photodamage upstream of autophagic-lysosomal dysregulation in human skin fibroblasts. J. Invest. Dermatol. 2011. 131(S1): S118-S118. PMID 20946361.  PMC3001288

Karn RC, Laukaitis CM. Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes. PLoS One. 2011:e20979. PMID: 21695125. PMC3114847

Kaleta EJ, Clark AE, Cherkaoui A, Wysocki VH, Ingram EL, Schrenzel J, Wolk DM. Comparative analysis of PCR-electrospray ionization/mass spectrometry (MS) and MALDI-TOF/MS for the identification of bacteria and yeast from positive blood culture bottles. 2011. Clin Chem. 57:1057-67. PMID: 21576270.

Kaleta EJ, Clark AE, Johnson DR, Gamage DC, Wysocki VH, Cherkaoui A, Schrenzel J, Wolk DM. Use of PCR coupled with electrospray ionization mass spectrometry for rapid identification of bacterial and yeast bloodstream pathogens from blood culture bottles. J Clin Microbiol. 2011 49:345-53. PMID: 21048006. PMCID: PMC3020459.

Lau SS, Kuhlman C, Shawn B, Bratton SB and Monks TJ. Role of Hydroquinone-Thiol Conjugates in Benzene-Mediated Toxicity. Chemico-Biol Int. 2010. 184: 212-217. PMID 20034486. PMC2846198

Fisher AA, Labenski MT, Monks TJ and Lau SS. Mass spectrometry-based methods to identify chemical modifications on proteins. I. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro. In: Gautier, J.-C. (ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press; 2010. 303-316.

Fisher AA, Labenski MT, Monks TJ and Lau SS. Mass spectrometry-based methods to identify chemical modifications on proteins: II. Utilization of LC-MS2 analyses to identify site-specific chemical protein adducts in vitro. In: Gautier, J.-C. (ed.). Drug Safety Evaluation  Series - Methods in Molecular Medicine. Humana Press; 2010. 317-326.

Labenski MT, Fisher AA, Monks TJ and Lau SS. Mass spectrometry-based methods to identify chemical modifications on proteins. III. 2-Dimensional western blotting coupled to LC-MS2 analysis to identify chemical-adducted proteins in urine. In: Gautier, J.-C. (ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press; 2010. 327-338.

Labenski MT, Fisher AA, Monks TJ and Lau SS. Mass spectrometry-based methods to identify chemical modifications on proteins. IV. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC2-MS2). In: Gautier, J.-C. (ed.). Drug Safety Evaluation Series - Methods of Molecular Medicine. Humana Press; 2010. 339-350.

Yoon JH, Choi EJ, and Parker R. Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae. J. Cell Biol. 2010. 189(5):813-827. PMID 20513766. PMC2878948

Bair WB, III., Cabello CM, Uchida K, Bause AS and Wondrak GT. GLO1 overexpression in human malignant melanoma. Melanoma Res. 2010. 20(2):85-96. PMID 20093988. PMC2891514

Crabbé A, Schurr MJ, Monsieurs P, Morici L, Schurr J, Wilson JW, Ott CM, Tsaprailis G, Stefanyshyn-Piper H and Nickerson CA. Transcriptional and proteomic response of Pseudomonas aeruginosa PAO1 to spaceflight conditions involves Hfq regulation and reveals a role for oxygen. Appl. Environ. Microbiol. 2010. 77(4):1221-1230. PMID 21169425. PMC3067220

Daskalova SM, Radder JE, Cichacz ZA, Olsen SH, Tsaprailis G, Mason H and Lopez LC. Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins--towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation. BMC Biotechnol. 2010. 10(1): 62. PMID 20735851. PMC2936419     

Xie L, Terrand J, Xu B, Tsaprailis G, Boyer J and Chen QM. Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation. Cardiovasc. Res. 2010. 87(4):628-635. PMID 20489058. PMC2920813

Lau SS, Kuhlman CL, Bratton SB and Monks TJ. Role of hydroquinone-thiol conjugates in benzene-mediated toxicity. Chem. Biol. Interact. 2010. 184: 212-217. PMID 20034486. PMC2846198

Majewski PM, Thurston RD, Ramalingam R, Kiela PR, Ghishan FK. Cooperative roleof NF-kappaB and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts. J Biol Chem. 2010 285:34828-38. PMID:20817730. PMCID: PMC2966098.


Xie LF, Xu BB, Pandey R, Tsaprailis G and Chen QM. Genomic and Proteomic Profiles of Oxidative Stress in Normal Human Diploid Fibroblasts. Biogerontology 2009. 10(2): 125-151. PMID 18654835.

Leinweber BD, Tsaprailis G, Monks TJ and Lau SS. Improved MALDI-TOF Imaging Yields Increased Protein Signals at High Molecular Mass. J. Am. Soc. Mass Spectrom. 2009. 20(1): 89-95. PMID 18926723. PMC2671225

Hruby VJ, Cai M, Dedek M, Qu H, Palmer E, Mayorov A, Trivedi D, Tsaprailis G and Yang Y. Peptide and non-peptide mimetics utilize different pathways for signal transduction. Adv. Exp. Med Biol. 2009. 611: 305-307. PMID 19400204.

González V, Guo K, Hurley LH and Sun D. Identification and characterization of nucleolin as a c-MYC G-quadruplex-binding protein. J. Biol. Chem. 2009. 284: 23622–23635.

González V and  Hurley LH. The c-MYC NHE III1:  function and regulation.  Ann. Rev. Pharmacol. Toxicol. 2009. 50: 111–129. PMID 19922264.

Brooks TA and Hurley LH. The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics.  Nat. Rev. Cancer 2009. 9: 849–861. PMID 19907434.

Labenski MT, Fisher AA, Lo HH, Monks T J and Lau SS. Protein electrophile-binding motifs: lysine-rich proteins are preferential targets of quinines. Drug Metab. Dispos. 2009. 37: 1211-1218. PMID 19251821. PMC2683689

Wolk DM, Blyn LB, Hall TA, Sampath R, Ranken R, Ivy C, Melton R, Matthews H, White N, Li F, Harpin V, Ecker DJ, Limbago B, McDougal LK, Wysocki VH, Cai M, Carroll KC. Pathogen profiling: rapid molecular characterization of
Staphylococcus aureus by PCR/electrospray ionization-mass spectrometry and correlation with phenotype. J Clin Microbiol. 2009 47:3129-37. PMID: 19710268. PMC2756914.

Hall TA, Sampath R, Blyn LB, Ranken R, Ivy C, Melton R, Matthews H, White N, Li F, Harpin V, Ecker DJ, McDougal LK, Limbago B, Ross T, Wolk DM, Wysocki V, Carroll KC. Rapid molecular genotyping and clonal complex assignment of Staphylococcus aureus isolates by PCR coupled to electrospray ionization-mass spectrometry. J Clin Microbiol. 2009 47:1733-41. PMID: 19297593. PMC2691079.